PPARdelta Activation Induces Metabolic and Contractile Maturation of Human Pluripotent Stem-Cell-Derived Cardiomyocytes

Researchers induced efficient human pluripotent stem-cell-derived cardiomyocytes maturation through metabolic-pathway modulations and found that peroxisome-proliferator-associated receptor (PPAR) signaling regulated glycolysis and fatty acid oxidation in an isoform-specific manner.