Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19

Scientists report on a systems-level blood immunomonitoring study of 37 adult patients diagnosed with COVID-19 and followed with up to 14 blood samples from acute to recovery phases of the disease.
[Cell Reports Medicine]
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Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis

Investigators demonstrated that intestinal G protein-coupled receptor 35 (Gpr35) expression was microbiota dependent and enhanced upon inflammation. Moreover, murine GPR35+ colonic macrophages were characterized by enhanced production of pro-inflammatory cytokines.
[Cell Reports]
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In Situ Neutrophil Efferocytosis Shapes T Cell Immunity to Influenza Infection

Newly infiltrated inflammatory monocytes became a chief pool of phagocytes and played a key role in the clearance of highly motile apoptotic neutrophils during the resolution phase.
[Nature Immunology]
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Satellite Cell Self-Renewal in Endurance Exercise Is Mediated by Inhibition of Mitochondrial Oxygen Consumption

Young adult mice were submitted to endurance exercise training and the function, differentiation, and metabolic characteristics of satellite cells were investigated in vivo and in vitro.
[Journal of Cachexia Sarcopenia and Muscle]
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Comparative Effects of Graphene and Molybdenum Disulfide on Human Macrophage Toxicity

M1 and M2 macrophage viability and activation were mainly found to be unaffected by few‐layer graphene and MoS2 at doses up to 50 µg mL−1.
[Small]
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Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-Inflammatory Effects Through SHIP1/STAT3 Complexes

Scientists report that IL10, but not IL6 signaling, induced formation of a complex between STAT3 and the inositol polyphosphate-5-phosphatase SHIP1 in macrophages.
[iScience]
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Correlative Study of Epigenetic Regulation of Tumor Microenvironment in Spindle Cell Melanomas and Cutaneous Malignant Peripheral Nerve Sheath Tumors

Scientists investigated the epigenetic regulation of promoters and gene bodies and their effect on the tumor microenvironment composition of cutaneous malignant peripheral nerve sheath tumors and spindle cell melanomas.
[Scientific Reports]
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Clonal Hematopoiesis and Non-Hematologic Disorders

Researchers review recent studies linking clonal hematopoiesis to altered immune function, inflammation, and non-malignant diseases of aging.
[Blood]
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Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration

The authors leveraged single-cell RNA sequencing in combination with in vivo lineage tracing and organoid models to finely map the trajectories of alveolar-lineage cells during injury repair and lung regeneration.
[Cell Stem Cell]
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Isolation of Murine Bone Marrow by Centrifugation or Flushing for the Analysis of Hematopoietic Cells – A Comparative Study

Researchers adapted a centrifugation-based method for the isolation of murine bone marrow and compared it to the traditional flushing method. Analysis of primary hematopoietic stem cells, immune cells, and megakaryocytes revealed a comparable distribution of cellular (sub)populations.
[Platelets]
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Specific Targeting of Ovarian Tumor-Associated Macrophages by Large, Anionic Nanoparticles

Researchers showed that relatively large anionic nanoparticles administered intraperitoneally selectively accumulated in tumor-associated macrophages.
[Proceedings of the National Academy of Sciences of the United States of America]
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