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myeloid cells

High Glucose Macrophage Exosomes Enhance Atherosclerosis by Driving Cellular Proliferation & Hematopoiesis

[iScience] Infusions of bone marrow-derived macrophages exposed to high glucose increased hematopoiesis, circulating myeloid cell numbers, and atherosclerotic lesions with an accumulation of macrophage foam and apoptotic cells.

Cell Type-Specific Roles of PAR1 in Coxsackievirus B3 Infection

[Scientific Reports] Investigators determined the effect of cell type-specific deletion of protease-activated receptor 1 (PAR1) in cardiac myocytes and cardiac fibroblasts on Coxsackievirus B3-induced myocarditis.

Characterization of Microglial Transcriptomes in the Brain and Spinal Cord of Mice in Early and Late Experimental Autoimmune Encephalomyelitis Using a RiboTag Strategy

[Scientific Reports] Scientists used a RiboTag strategy to characterize ribosome-bound mRNA only in microglia without incurring possible transcriptional changes after cell isolation.

The Zinc Finger Transcription Factor, KLF2, Protects against COVID-19 Associated Endothelial Dysfunction

[Signal Transduction and Targeted Therapy] Scientists demonstrated that the expression of KLF2 was reduced and monocyte adhesion was increased in endothelial cells treated with COVID-19 patient serum due to elevated levels of pro-adhesive molecules, ICAM1 and VCAM1.

Human Immunodeficiency Virus and Human Cytomegalovirus Coinfection of Infant Tonsil Epithelium May Synergistically Promote Both HIV-1 and HCMV Spread and Infection

[Journal of Virology] Scientists showed that cell-free HIV-1 and its proteins gp120 and tat induce the disruption of tonsil epithelial tight junctions and increase paracellular permeability, which facilitates HCMV spread within the tonsil mucosa.

Polymeric Aggregate-Embodied Hybrid Nitric-Oxide-Scavenging and Sequential Drug-Releasing Hydrogel for Combinatorial Treatment of Rheumatoid Arthritis

[Advanced Materials] The rational design of an injectable in situ polymeric aggregate-embodied hybrid nitric oxide (NO)-scavenging and sequential drug-releasing gel platform for the combinatorial treatment of rheumatoid arthritis by incorporating a “clickable” NO-cleavable cross-linker was reported.

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