myeloid cells

[Nature Communications] Investigators found that the interferon gamma-regulated transcriptional program in macrophages is controlled by ADP-ribosylation of STAT1α, a post-translational modification resulting in the site-specific covalent attachment of ADP-ribose moieties.

[Stem Cell Reports] Scientists described a defined, serum-free, open-source medium for the differentiation of iPSC-derived macrophages. This medium was equally capable of maintaining these cells compared with commercial alternatives.

[Journal of Clinical Oncology] 120 patients with de novo acute myeloid leukemia received either romyelocel-L infusion on day nine with granulocyte colony-stimulating factor (G-CSF) starting daily on day fourteen (treatment group) or G-CSF daily alone on day fourteen (control) until absolute neutrophil count recovery to 500/µL.

[Blood] Investigators reported results of a Phase III trial to evaluate the efficacy of omidubicel compared to standard umbilical cord blood transplantation.

[Nature] Scientists discovered COVID-19 disease-associated microglia and astrocyte subpopulations that share features with pathological cell states reported in human neurodegenerative disease4–6.

[Scientific Reports] Researchers developed and applied such assays to measure the levels of leucine-rich repeat kinase 2 as well as the phosphorylation of LRRK2 itself or one of its substrates, Rab10.