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Pulmonary Cell NewsInvestigators found that the interferon gamma-regulated transcriptional program in macrophages is controlled by ADP-ribosylation of STAT1α, a post-translational modification resulting in the site-specific covalent attachment of ADP-ribose moieties.
[Nature Communications]
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Gupte, R., Nandu, T., & Kraus, W. L. (2021). Nuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages. Nature Communications, 12(1), 3931. https://doi.org/10.1038/s41467-021-24225-2 Cite
