Tag results:
myeloid cells
Umbilical & Placental Cell News
iNKT Cells Coordinate Immune Pathways to Enable Engraftment in Nonconditioned Hosts
[Life Science Alliance] Using a human umbilical cord blood xenotransplantation model, we show here that co-transplanted allogeneic CD4+ iNKT cells interact with monocytes and T cells in the graft to coordinate pro-hematopoietic and immunoregulatory pathways.
Immunology of Infectious Disease News
Multi-Omic Profiling Reveals Widespread Dysregulation of Innate Immunity and Hematopoiesis in COVID-19
[Journal of Experimental Medicine] Researchers performed multi-omic single-cell immune profiling of 64 COVID-19 patients across the full range of disease severity, from outpatients with mild disease to fatal cases.
Immunology of Infectious Disease News
Helminth Derived Factors Inhibit Neutrophil Extracellular Trap Formation and Inflammation in Bacterial Peritonitis
[Scientific Reports] Scientists reported that helminth parasite excretory/secretory factors termed as parasitic ligands inhibited ROS-induced NETs by blocking the activation of nonselective calcium permeable channel Transient Receptor Potential Melastatin 2.
Human Immunology News
HIF-1α Is a Negative Regulator of Interferon Regulatory Factors: Implications for Interferon Production by Hypoxic Monocytes
[Proceedings of the National Academy of Sciences of the United States of America] To understand the pathophysiology of COVID-19 infection, it is necessary to understand cell function during hypoxia. Researchers investigated aspects of human monocyte activation under hypoxic conditions.
Human Immunology News
Tissue-Resident Macrophages Provide a Pro-Tumorigenic Niche to Early NSCLC Cells
[Nature] Researchers identified distinct populations of macrophages that were enriched in human and mouse lung tumors.
Human Immunology News
MYC-Mediated Early Glycolysis Negatively Regulates Proinflammatory Responses by Controlling IRF4 in Inflammatory Macrophages
[Cell Reports] Metabolic and molecular analyses reveal that MYC, but not hypoxia inducible factor 1, was involved in enhancing early glycolytic flux during inflammatory macrophage polarization.