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myeloid cells

iNKT Cells Coordinate Immune Pathways to Enable Engraftment in Nonconditioned Hosts

[Life Science Alliance] Using a human umbilical cord blood xenotransplantation model, we show here that co-transplanted allogeneic CD4+ iNKT cells interact with monocytes and T cells in the graft to coordinate pro-hematopoietic and immunoregulatory pathways.

Multi-Omic Profiling Reveals Widespread Dysregulation of Innate Immunity and Hematopoiesis in COVID-19

[Journal of Experimental Medicine] Researchers performed multi-omic single-cell immune profiling of 64 COVID-19 patients across the full range of disease severity, from outpatients with mild disease to fatal cases.

Helminth Derived Factors Inhibit Neutrophil Extracellular Trap Formation and Inflammation in Bacterial Peritonitis

[Scientific Reports] Scientists reported that helminth parasite excretory/secretory factors termed as parasitic ligands inhibited ROS-induced NETs by blocking the activation of nonselective calcium permeable channel Transient Receptor Potential Melastatin 2.

HIF-1α Is a Negative Regulator of Interferon Regulatory Factors: Implications for Interferon Production by Hypoxic Monocytes

[Proceedings of the National Academy of Sciences of the United States of America] To understand the pathophysiology of COVID-19 infection, it is necessary to understand cell function during hypoxia. Researchers investigated aspects of human monocyte activation under hypoxic conditions.

Tissue-Resident Macrophages Provide a Pro-Tumorigenic Niche to Early NSCLC Cells

[Nature] Researchers identified distinct populations of macrophages that were enriched in human and mouse lung tumors.

MYC-Mediated Early Glycolysis Negatively Regulates Proinflammatory Responses by Controlling IRF4 in Inflammatory Macrophages

[Cell Reports] Metabolic and molecular analyses reveal that MYC, but not hypoxia inducible factor 1, was involved in enhancing early glycolytic flux during inflammatory macrophage polarization.

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