myeloid cells

[Science Translational Medicine] Extended antibody treatment of mice caused marked body weight gain, an indicator of enhanced body fluid retention. This was associated with an increase of ECM–remodeling metalloproteinases (MMPs), namely MMP2 and MMP3, and enhanced deposition of hyaluronan and proteoglycans, leading to skin thickening.

[Science Translational Medicine] To examine the ontogeny and function of MS1 cells, scientists developed a cellular model for inducing CD14+ MS1 monocytes by treating human hematopoietic stem and progenitor cells from healthy bone marrow donors in culture with plasma from patients with severe bacterial infection or SARS-CoV-2 infection.

[Bone Marrow Transplantation] Investigators compared 32 patients who underwent unrelated donor (UD) hematopoietic stem cell transplantation (HSCT) using cryopreserved peripheral blood stem cells (PBSC) during the COVID-19 pandemic with 32 patients who underwent UD HSCT using fresh PBSC in the previous period.

[Cell Death & Disease] Researchers found that Ripk3−/− mice had significantly more severe pancreatic edema and inflammation associated with macrophage and neutrophil infiltration than control mice.

[Cell Death & Disease] The authors investigated the involvement of TAM receptor kinases Mer and Axl in the muscle regeneration process by studying the muscle repair following cardiotoxin-induced injury in Mer−/− mice.In vitro inhibition of TAM kinase signaling in C2C12 myoblasts resulted in decreased viability and in impaired myotube growth.

[Cell] To aid in understanding tissue-specific pathophysiology, researchers compiled a single-cell transcriptome atlas of human oral mucosa in healthy individuals and patients with periodontitis.