Cis-Acting Lnc-Cxcl2 Restrains Neutrophil-Mediated Lung Inflammation by Inhibiting Epithelial Cell CXCL2 Expression in Virus Infection

Scientists identified an inducible lncRNA in the Cxcl2 gene locus, lnc-Cxcl2, which could selectively inhibit Cxcl2 expression in mouse lung epithelial cells but not in macrophages.
[Proceedings of the National Academy of Sciences of the United States of America]
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Signatures of Plasticity, Metastasis, and Immunosuppression in an Atlas of Human Small Cell Lung Cancer

Scientists sequenced 155,098 transcriptomes from 21 human biospecimens, including 54,523 small cell lung cancer (SCLC) transcriptomes. They observed greater tumor diversity in SCLC than lung adenocarcinoma, driven by canonical, intermediate, and admixed subtypes.
[Cancer Cell]
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AXL Cooperates with EGFR to Mediate Neutrophil Elastase-Induced Migration of Prostate Cancer Cells

Scientists reported that neutrophil elastase triggered dose-dependent ERK signaling and cell migration in a panel of prostate cell lines representing the spectrum of prostate cell malignancy.
[iScience]
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Machine Learning Identification of Specific Changes in Myeloid Cell Phenotype during Bloodstream Infections

An eight-color antibody panel was used to identify seven monocyte and two dendritic cell subsets. In the learning cohort, immunophenotyping was applied to control subjects, postoperative heart surgery patients, as a model of noninfectious inflammatory responses, and blood culture-positive patients.
[Scientific Reports]
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IL-33-Induced Metabolic Reprogramming Controls the Differentiation of Alternatively Activated Macrophages and the Resolution of Inflammation

Scientists showed that uncoupling protein-2-mediated mitochondrial reprogramming and the transcription factor GATA3 specifically controlled the differentiation of pro-resolving alternatively activated macrophages in response to the alarmin IL-33.
[Immunity]
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Therapeutic Melanoma Inhibition by Local Micelle-Mediated Cyclic Nucleotide Repression

Researchers demonstrated that single-cell sequencing of melanoma-infiltrating immune cells showed that adenylate cyclase inhibitor micelles reduced the number of anti-inflammatory myeloid cells and checkpoint receptor expression on T cells.
[Nature Communications]
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Genetic Deletion of the Cannabinoid Receptors CB1 and CB2 Enhances Inflammation with Diverging Effects on Skin Wound Healing in Mice

In order to clarify the role of endocannabinoid system receptors in wound healing, excisional wounds were created on wildtype and CB1 and CB2 knockout mice.
[Life Sciences]
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Downregulation of Phosphoglycerate Mutase 5 Improves Microglial Inflammasome Activation after Traumatic Brain Injury

Researchers evaluated the effects of Pgam5 on neurological deficits and neuroinflammation of controlled cortical impact-induced TBI mouse model in vivo and LPS+ ATP-induced microglia model in vitro.
[Cell Death Discovery]
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Synapse Development Is Regulated by Microglial THIK-1 K+ Channels

Microglial ramification, motility, and cytokine release are regulated by tonically active THIK-1 K+ channels on the microglial plasma membrane. Researchers examined whether these channels played a role in phagocytosis.
[Proceedings of the National Academy of Sciences of the United States of America]
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Mechanism of Neutrophil Extracellular Traps Generation and Their Role in Trophoblast Apoptosis in Gestational Diabetes Mellitus

The authors revealed the mechanism of neutrophil extracellular traps generation and their role in trophoblast apoptosis in gestational diabetes mellitus.
[Cellular Signalling]
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A CIBERSORTx-Based Immune-Cell Scoring System Could Independently Predict Prognosis of Myelodysplastic Syndrome Patients

The authors adopted CIBERSORTx to estimate the relative fractions of 22 subtypes of immune cells in the bone marrow of 316 myelodysplastic syndrome patients and correlated the results with clinical outcomes.
[Blood Advances]
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