Ibrutinib Suppresses Early Megakaryopoiesis but Enhances Proplatelet Formation

Researchers investigated the mechanism by which ibrutinib induces thrombocytopenia using cord blood CD34+ hematopoietic stem cells, a human megakaryoblastic cell line, and C57BL/6 mice.
[Thrombosis and Haemostasis]
Huang, J., Huang, S., Ma, Z., Lin, X., Li, X., Huang, X., Wang, J., Ye, W., Li, Y., He, D., Yang, M., Pan, J., Ling, Q., Li, F., Mao, S., Wang, H., Wang, Y., & Jin, J. (2020). Ibrutinib Suppresses Early Megakaryopoiesis but Enhances Proplatelet Formation. Thrombosis and Haemostasis. https://doi.org/10.1055/s-0040-1716530 Cite
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Single-Cell Genomics Reveals a Novel Cell State during Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human

To reveal the trajectories of smooth muscle cell (SMC) transdifferentiation during atherosclerosis and to identify molecular targets for disease therapy, researchers combined SMC fate mapping and single-cell RNA sequencing of both mouse and human atherosclerotic plaques.
[Circulation]
Pan Huize, Xue Chenyi, Auerbach Benjamin J., Fan Jiaxin, Bashore Alexander C., Cui Jian, Yang Dina Y., Trignano Sarah B., Liu Wen, Shi Jianting, Ihuegbu Chinyere O., Bush Erin C., Worley Jeremy, Vlahos Lukas, Laise Pasquale, Solomon Robert A., Connolly Edward S., Califano Andrea, Sims Peter A., … Reilly Muredach P. (n.d.). Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human. Circulation, 0(0). https://doi.org/10.1161/CIRCULATIONAHA.120.048378 Cite
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Ribosomal Profiling During Prion Disease Uncovers Progressive Translational Derangement in Glia but Not in Neurons

The authors applied a combination of translating ribosome affinity purification and ribosome profiling to identify biologically relevant prion-induced changes during disease progression in a cell-type specific and genome-wide manner. Terminally diseased mice with severe neurological symptoms showed extensive alterations in astrocytes and microglia.
[eLife]
Scheckel, C., Imeri, M., Schwarz, P., & Aguzzi, A. (2020). Ribosomal profiling during prion disease uncovers progressive translational derangement in glia but not in neurons. ELife, 9, e62911. https://doi.org/10.7554/eLife.62911 Cite
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An Optimized Quantitative Proteomics Method Establishes the Cell Type-Resolved Mouse Brain Secretome

High‐performance secretome protein enrichment with click sugars method was used to identify the secretory response of brain slices upon LPS‐induced neuroinflammation and to establish the cell type‐resolved mouse brain secretome resource using primary astrocytes, microglia, neurons, and oligodendrocytes.
[EMBO Journal]
Tüshaus, J., Müller, S. A., Kataka, E. S., Zaucha, J., Sebastian Monasor, L., Su, M., Güner, G., Jocher, G., Tahirovic, S., Frishman, D., Simons, M., & Lichtenthaler, S. F. (2020). An optimized quantitative proteomics method establishes the cell type-resolved mouse brain secretome. The EMBO Journal, n/a(n/a), e105693. https://doi.org/10.15252/embj.2020105693 Cite
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Omental Macrophages Secrete Chemokine Ligands That Promote Ovarian Cancer Colonization of the Omentum via CCR1

Investigators report that omental macrophages promoted the migration and colonization of ovarian cancer cells to the omentum through the secretion of chemokine ligands that interacted with chemokine receptor 1.
[Communications Biology]
Krishnan, V., Tallapragada, S., Schaar, B., Kamat, K., Chanana, A. M., Zhang, Y., Patel, S., Parkash, V., Rinker-Schaeffer, C., Folkins, A. K., Rankin, E. B., & Dorigo, O. (2020). Omental macrophages secrete chemokine ligands that promote ovarian cancer colonization of the omentum via CCR1. Communications Biology, 3(1), 1–13. https://doi.org/10.1038/s42003-020-01246-z Cite
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Tackling TAMs for Cancer Immunotherapy: It’s Nano Time

The tumor microenvironment (TME) is a highly complex environment that surrounds tumors. Interactions between cancer cells/non-cancerous cells and cells/non-cell components in the TME support tumor initiation, development, and metastasis. Of the cell types in the TME, tumor-associated macrophages (TAMs) have gained attention owing to their crucial roles in supporting tumors and conferring therapy resistance.
[Trends in Pharmacological Sciences]
Yang, Y., Guo, J., & Huang, L. (2020). Tackling TAMs for Cancer Immunotherapy: It’s Nano Time. Trends in Pharmacological Sciences, 41(10), 701–714. https://doi.org/10.1016/j.tips.2020.08.003 Cite
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Gold Nanorod-Based Nanoplatform Catalyzes Constant NO Generation and Protects from Cardiovascular Injury

Researchers found that NanoNOS greatly suppressed injury-driven monocyte-endothelial cell adhesion, suggesting NanoNOS treatment could help prevent cardiovascular diseases.
[ACS Nano]
Li, H., Yan, J., Meng, D., Cai, R., Gao, X., Ji, Y., Wang, L., Chen, C., & Wu, X. (2020). Gold Nanorod-Based Nanoplatform Catalyzes Constant NO Generation and Protects from Cardiovascular Injury. ACS Nano. https://doi.org/10.1021/acsnano.0c03629 Cite
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Lung Mesenchymal Cells Elicit Lipid Storage in Neutrophils That Fuel Breast Cancer Lung Metastasis

In breast cancer models, scientists found that neutrophils were induced to accumulate neutral lipids upon interaction with resident mesenchymal cells in the premetastatic lung.
[Nature Immunology]
Li, P., Lu, M., Shi, J., Gong, Z., Hua, L., Li, Q., Lim, B., Zhang, X. H.-F., Chen, X., Li, S., Shultz, L. D., & Ren, G. (2020). Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis. Nature Immunology, 1–12. https://doi.org/10.1038/s41590-020-0783-5 Cite
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Roles of Fibrinolytic Factors in the Alterations in Bone Marrow Hematopoietic Stem/Progenitor Cells during Bone Repair

Osteoblasts, osteoclasts, chondrocytes, and macrophages involved in the bone repair process originate from hematopoietic stem/progenitor cells and mesenchymal stem cells in the bone marrow.
[Inflammation and Regeneration]
Okada, K., Nishioka, M., & Kaji, H. (2020). Roles of fibrinolytic factors in the alterations in bone marrow hematopoietic stem/progenitor cells during bone repair. Inflammation and Regeneration, 40(1), 22. https://doi.org/10.1186/s41232-020-00128-5 Cite
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M. tuberculosis Infection of Human iPSDM Reveals Complex Membrane Dynamics during Xenophagy Evasion

Researchers used human induced pluripotent stem cell derived macrophages to study the human macrophage response to Mycobacterium tuberculosis infection induced by the ESX-1 Type-VII secretion system.
[Journal of Cell Science]
Bernard, E. M., Fearns, A., Bussi, C., Santucci, P., Peddie, C. J., Lai, R. J., Collinson, L. M., & Gutierrez, M. G. (2020). M. tuberculosis infection of human iPSDM reveals complex membrane dynamics during xenophagy evasion. Journal of Cell Science. https://doi.org/10.1242/jcs.252973 Cite
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Distinct Macrophage Populations and Phenotypes Associated with IL-4 Mediated Immunomodulation at the Host Implant Interface

Researchers use an in vivo implantation model to analyze how immunomodulation via an IL-4 eluting implant affects distinct macrophage populations at the tissue-implant interface and how this may affect downstream regenerative processes.
[Biomaterials Science]
Hachim, D., LoPresti, S. T., Rege, R. D., Umeda, Y., Iftikhar, A., Nolfi, A. L., Skillen, C. D., & Brown, B. N. (2020). Distinct macrophage populations and phenotypes associated with IL-4 mediated immunomodulation at the host implant interface. Biomaterials Science. https://doi.org/10.1039/D0BM00568A Cite
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