Tag results:

myeloid cells

Life and Death of Microglia: Mechanisms Governing Microglial States and Fates

[Immunology Letters] The authors summarize the current knowledge on the possible microglial states during development, homeostasis, and perturbation.

Toward In Vitro Production of Platelet from Induced Pluripotent Stem Cells

[Stem Cell Reviews and Reports] The authors focus on how to progress in vitro generation of platelets from stem cell, especially iPSCs, and describe some of the successful strategies that can be easily used in clinic.

Ubiquitin-Like Protein 3 (UBL3) Is Required for MARCH Ubiquitination of Major Histocompatibility Complex Class II and CD86

[Nature Communications] Researchers showed, using a genome-wide CRISPR knockout screen, that UBL3 was a necessary component of ubiquitination-mediated trafficking of major histocompatibility complex class II and CD86 in mice and in humans.

Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis

[Circulation Research] Genetic deletion of pyruvate kinase muscle 2 (PKM2) in myeloid cells or limiting its nuclear translocation reduced atherosclerosis by suppressing inflammation and enhancing efferocytosis.

CCR2/CCR5 Inhibitor Permits the Radiation-Induced Effector T Cell Infiltration in Pancreatic Adenocarcinoma

[Journal of Experimental Medicine] Using PDAC mouse models, scientists demonstrated that radiation therapy followed by anti-PD-1 antibody and prolonged treatment with CCR2/5i conferred better antitumor efficacy than other combination treatments tested.

Single-Cell Characterization of Leukemic and Non-Leukemic Immune Repertoires in CD8+ T Cell Large Granular Lymphocytic Leukemia

[Nature Communications] Utilizing single-cell RNA and T cell receptor profiling, researchers showed that irrespective of STAT3 mutation status, T cell large granular lymphocytic leukemia clonotypes were more cytotoxic and exhausted than healthy reactive clonotypes.