Generation and Manipulation of Human iPSC-Derived Platelets

The authors focus on the current status of the development, application and manipulation of iPSC-derived platelet-like particles, which has been leading the field of regenerative medicine using iPSC-derived blood cells and has reached the first-in-human clinical trial.
[Cellular and Molecular Life Sciences]
Sugimoto, N., & Eto, K. (2021). Generation and manipulation of human iPSC-derived platelets. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-020-03749-8 Cite
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Evaluation of Angiogenic Signaling Molecules Associated with Reactive Thrombocytosis in an Iron-Deficient Rat Model

A review of the bone marrow showed an increase in the number of megakaryocytes, vascular structures, as well as increased intensity of stain for VEGF, and CXC chemokine receptor 4 in rats with iron deficiency anemia compared to controls.
[Pediatric Research]
Garcia, J., Mankin, P., Gnanamony, M., & de Alarcon, P. A. (2021). Evaluation of angiogenic signaling molecules associated with reactive thrombocytosis in an iron-deficient rat model. Pediatric Research, 1–6. https://doi.org/10.1038/s41390-020-01318-0 Cite
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Role of miRNAs Shuttled by Mesenchymal Stem Cell-Derived Small Extracellular Vesicles in Modulating Neuroinflammation

Scientists identified nine miRNAs significantly dysregulated in IFN-γ-primed MSCs, but present at different levels in their derived small extracellular vesicles.
[Scientific Reports]
Giunti, D., Marini, C., Parodi, B., Usai, C., Milanese, M., Bonanno, G., Kerlero de Rosbo, N., & Uccelli, A. (2021). Role of miRNAs shuttled by mesenchymal stem cell-derived small extracellular vesicles in modulating neuroinflammation. Scientific Reports, 11(1), 1740. https://doi.org/10.1038/s41598-021-81039-4 Cite
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TEAD1 Protects against Necroptosis in Postmitotic Cardiomyocytes through Regulation of Nuclear DNA-Encoded Mitochondrial Genes

The authors reported that TEAD1 is required for postmitotic cardiomyocyte (CM) survival. They found that adult mice with ubiquitous or CM-specific loss of Tead1 present with a rapid lethality due to an acute-onset dilated cardiomyopathy.
[Cell Death & Differentiation]
Liu, J., Wen, T., Dong, K., He, X., Zhou, H., Shen, J., Fu, Z., Hu, G., Ma, W., Li, J., Wang, W., Wang, L., Akerberg, B. N., Xu, J., Osman, I., Zheng, Z., Wang, W., Du, Q., Pu, W. T., … Zhou, J. (2021). TEAD1 protects against necroptosis in postmitotic cardiomyocytes through regulation of nuclear DNA-encoded mitochondrial genes. Cell Death & Differentiation, 1–15. https://doi.org/10.1038/s41418-020-00732-5 Cite
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Listeria monocytogenes Upregulates Mitochondrial Calcium Signaling To Inhibit LC3-Associated Phagocytosis as a Survival Strategy

Invasion of macrophages by L. monocytogenes induced mitochondrial Ca2+ (mtCa2+) uptake through the mtCa2+ uniporter, which in turn increased acetyl-coenzyme A production by pyruvate dehydrogenase.
[Nature Microbiology]
Li, T., Kong, L., Li, X., Wu, S., Attri, K. S., Li, Y., Gong, W., Zhao, B., Li, L., Herring, L. E., Asara, J. M., Xu, L., Luo, X., Lei, Y. L., Ma, Q., Seveau, S., Gunn, J. S., Cheng, X., Singh, P. K., … Wen, H. (2021). Listeria monocytogenes upregulates mitochondrial calcium signalling to inhibit LC3-associated phagocytosis as a survival strategy. Nature Microbiology, 1–14. https://doi.org/10.1038/s41564-020-00843-2 Cite
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ATG7 Is Dispensable for LC3–PE Conjugation in Thioglycolate-Elicited Mouse Peritoneal Macrophages

Using atg5-deficient and atg7-/- macrophages, scientists provide evidence that loss of ATG5 but not of ATG7 resulted in LC3-II depletion.
[Autophagy]
Vujić, N., Bradić, I., Goeritzer, M., Kuentzel, K. B., Rainer, S., Kratky, D., & Radović, B. (2021). ATG7 is dispensable for LC3–PE conjugation in thioglycolate-elicited mouse peritoneal macrophages. Autophagy, 0(0), 1–6. https://doi.org/10.1080/15548627.2021.1874132 Cite
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Dopamine Improves Chemotherapeutic Efficacy for Pancreatic Cancer by Regulating Macrophage-Derived Inflammations

The roles and mechanisms of dopamine to affect the chemotherapeutic efficacy for pancreatic cancer were studied. Multi-omics results revealed that there was a tumor-promoting vicious cycle involving murine pancreatic cancer cells and tumor-associated macrophages.
[Cancer Immunology Immunotherapy]
Liu, Q., Zhang, R., Zhang, X., Liu, J., Wu, H., Li, Y., Cui, M., Li, T., Song, H., Gao, J., Zhang, Y., Yang, S., & Liao, Q. (2021). Dopamine improves chemotherapeutic efficacy for pancreatic cancer by regulating macrophage-derived inflammations. Cancer Immunology, Immunotherapy. https://doi.org/10.1007/s00262-020-02816-0 Cite
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Role of miRNAs Shuttled by Mesenchymal Stem Cell-Derived Small Extracellular Vesicles in Modulating Neuroinflammation

Investigators showed that miR-467f and miR-466q modulate the pro-inflammatory phenotype of activated N9 microglia cells and of primary microglia acutely isolated from late symptomatic SOD1G93A mice, a murine ALS model, by downregulating Tnf and Il1b expression.
[Scientific Reports]
Giunti, D., Marini, C., Parodi, B., Usai, C., Milanese, M., Bonanno, G., Kerlero de Rosbo, N., & Uccelli, A. (2021). Role of miRNAs shuttled by mesenchymal stem cell-derived small extracellular vesicles in modulating neuroinflammation. Scientific Reports, 11(1), 1740. https://doi.org/10.1038/s41598-021-81039-4 Cite
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Model Complexity as Determining Factor for In Vitro Nanosafety Studies: Effects of Silver and Titanium Dioxide Nanomaterials in Intestinal Models

Researchers studied the cytotoxic, proinflammatory, and DNA damaging properties of polyvinylpyrrolidone‐capped silver and titanium dioxide engineered nanomaterials in four in vitro models of increasing complexity—from proliferating Caco‐2 and HT29‐MTX‐E12 monocultures to long‐term transwell triple cultures including THP‐1 macrophages to reproduce the human intestine in healthy versus inflamed‐like state.
[Small]
Kämpfer, A. A. M., Busch, M., Büttner, V., Bredeck, G., Stahlmecke, B., Hellack, B., Masson, I., Sofranko, A., Albrecht, C., & Schins, R. P. F. (n.d.). Model Complexity as Determining Factor for In Vitro Nanosafety Studies: Effects of Silver and Titanium Dioxide Nanomaterials in Intestinal Models. Small, n/a(n/a), 2004223. https://doi.org/https://doi.org/10.1002/smll.202004223 Cite
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Adipose Tissue Inflammation and Systemic Insulin Resistance in Mice with Diet-Induced Obesity Is Possibly Associated with Disruption of PFKFB3 in Hematopoietic Cells

Researchers examined a role for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in hematopoietic cells in regulating white adipose tissue inflammation and systemic insulin sensitivity.
[Laboratory Investigation]
Zhu, B., Guo, X., Xu, H., Jiang, B., Li, H., Wang, Y., Yin, Q., Zhou, T., Cai, J. J., Glaser, S., Meng, F., Francis, H., Alpini, G., & Wu, C. (2021). Adipose tissue inflammation and systemic insulin resistance in mice with diet-induced obesity is possibly associated with disruption of PFKFB3 in hematopoietic cells. Laboratory Investigation, 1–13. https://doi.org/10.1038/s41374-020-00523-z Cite
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EGR1 Is a Gatekeeper of Inflammatory Enhancers in Human Macrophages

Researchers analyzed the molecular determinants of monocytic and macrophagic commitment by profiling the EGR1 transcription factor. EGR1 is essential for monopoiesis and binds enhancers that regulate monocytic developmental genes such as CSF1R.
[Science Advances]
EGR1 is a gatekeeper of inflammatory enhancers in human macrophages | Science Advances. (n.d.). Retrieved January 18, 2021, from https://advances.sciencemag.org/content/7/3/eaaz8836 Cite
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