Researchers investigated the mechanism by which ibrutinib induces thrombocytopenia using cord blood CD34+ hematopoietic stem cells, a human megakaryoblastic cell line, and C57BL/6 mice.
[Thrombosis and Haemostasis]
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Huang, J., Huang, S., Ma, Z., Lin, X., Li, X., Huang, X., Wang, J., Ye, W., Li, Y., He, D., Yang, M., Pan, J., Ling, Q., Li, F., Mao, S., Wang, H., Wang, Y., & Jin, J. (2020). Ibrutinib Suppresses Early Megakaryopoiesis but Enhances Proplatelet Formation. Thrombosis and Haemostasis. https://doi.org/10.1055/s-0040-1716530 Cite
To reveal the trajectories of smooth muscle cell (SMC) transdifferentiation during atherosclerosis and to identify molecular targets for disease therapy, researchers combined SMC fate mapping and single-cell RNA sequencing of both mouse and human atherosclerotic plaques.
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Pan Huize, Xue Chenyi, Auerbach Benjamin J., Fan Jiaxin, Bashore Alexander C., Cui Jian, Yang Dina Y., Trignano Sarah B., Liu Wen, Shi Jianting, Ihuegbu Chinyere O., Bush Erin C., Worley Jeremy, Vlahos Lukas, Laise Pasquale, Solomon Robert A., Connolly Edward S., Califano Andrea, Sims Peter A., … Reilly Muredach P. (n.d.). Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human. Circulation, 0(0). https://doi.org/10.1161/CIRCULATIONAHA.120.048378 Cite
The authors applied a combination of translating ribosome affinity purification and ribosome profiling to identify biologically relevant prion-induced changes during disease progression in a cell-type specific and genome-wide manner. Terminally diseased mice with severe neurological symptoms showed extensive alterations in astrocytes and microglia.
High‐performance secretome protein enrichment with click sugars method was used to identify the secretory response of brain slices upon LPS‐induced neuroinflammation and to establish the cell type‐resolved mouse brain secretome resource using primary astrocytes, microglia, neurons, and oligodendrocytes.
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Tüshaus, J., Müller, S. A., Kataka, E. S., Zaucha, J., Sebastian Monasor, L., Su, M., Güner, G., Jocher, G., Tahirovic, S., Frishman, D., Simons, M., & Lichtenthaler, S. F. (2020). An optimized quantitative proteomics method establishes the cell type-resolved mouse brain secretome. The EMBO Journal, n/a(n/a), e105693. https://doi.org/10.15252/embj.2020105693 Cite
Investigators report that omental macrophages promoted the migration and colonization of ovarian cancer cells to the omentum through the secretion of chemokine ligands that interacted with chemokine receptor 1.
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Krishnan, V., Tallapragada, S., Schaar, B., Kamat, K., Chanana, A. M., Zhang, Y., Patel, S., Parkash, V., Rinker-Schaeffer, C., Folkins, A. K., Rankin, E. B., & Dorigo, O. (2020). Omental macrophages secrete chemokine ligands that promote ovarian cancer colonization of the omentum via CCR1. Communications Biology, 3(1), 1–13. https://doi.org/10.1038/s42003-020-01246-z Cite
The tumor microenvironment (TME) is a highly complex environment that surrounds tumors. Interactions between cancer cells/non-cancerous cells and cells/non-cell components in the TME support tumor initiation, development, and metastasis. Of the cell types in the TME, tumor-associated macrophages (TAMs) have gained attention owing to their crucial roles in supporting tumors and conferring therapy resistance.
[Trends in Pharmacological Sciences]
Researchers found that NanoNOS greatly suppressed injury-driven monocyte-endothelial cell adhesion, suggesting NanoNOS treatment could help prevent cardiovascular diseases.
In breast cancer models, scientists found that neutrophils were induced to accumulate neutral lipids upon interaction with resident mesenchymal cells in the premetastatic lung.
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Li, P., Lu, M., Shi, J., Gong, Z., Hua, L., Li, Q., Lim, B., Zhang, X. H.-F., Chen, X., Li, S., Shultz, L. D., & Ren, G. (2020). Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis. Nature Immunology, 1–12. https://doi.org/10.1038/s41590-020-0783-5 Cite
Osteoblasts, osteoclasts, chondrocytes, and macrophages involved in the bone repair process originate from hematopoietic stem/progenitor cells and mesenchymal stem cells in the bone marrow.
[Inflammation and Regeneration]
Researchers used human induced pluripotent stem cell derived macrophages to study the human macrophage response to Mycobacterium tuberculosis infection induced by the ESX-1 Type-VII secretion system.
[Journal of Cell Science]
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Researchers use an in vivo implantation model to analyze how immunomodulation via an IL-4 eluting implant affects distinct macrophage populations at the tissue-implant interface and how this may affect downstream regenerative processes.
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Hachim, D., LoPresti, S. T., Rege, R. D., Umeda, Y., Iftikhar, A., Nolfi, A. L., Skillen, C. D., & Brown, B. N. (2020). Distinct macrophage populations and phenotypes associated with IL-4 mediated immunomodulation at the host implant interface. Biomaterials Science. https://doi.org/10.1039/D0BM00568A Cite