myeloid cells

[Pliant Therapeutics, Inc.] Pliant Therapeutics, Inc. announced positive data from its expanded PLN-74809 Phase Ib proof-of-mechanism trial. Results showed that PLN-74809 inhibited TGF-β activation on day seven by up to 92% and 76% at six and twenty-four hours, respectively, following dosing.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers found that TLR4 signaling in vascular endothelial cells and downstream NADPH oxidase 4 expression mediate the arrest of neutrophils, a step upstream of their extravasation.

[Cell Reports] The authors identified an interferon-γ-regulated subset of monocytes, CCR2+ monocytes, as a driver of lung damage during influenza A virus infection.

[FASEB Journal] Researchers studied the crosstalk between hyaluronan in the tumor microenvironment and macrophages dependent lymphangiogenesis, providing new insight into tumor microenvironment remodeling and macrophages in breast cancer lymphangiogenesis.

[Journal of Reproductive Immunology] Investigators hypothesized that decidual leukocytes were altered by maternal SARS-CoV-2 infection in pregnancy and that this decidual immune response was shaped by the timing of infection during gestation.

[Frontiers in Cell and Developmental Biology] Beneficial effects were observed with Rapamycin treatment as it decreased the gliotic response and prevented the development of newly formed blood vessels.