myeloid cells

[Cell Reports] The authors identified renal Klotho and inorganic phosphate as extrinsic factors that antagonistically regulate HSC maintenance in the bone marrow.

[Biophysical Journal] Researchers developed a platform that utilized orthogonal photopatterning of stiffness and adhesivity gradients to fabricate individually accessible wells with discrete ECM conditions.

[Cancer Gene Therapy] In hepatic cells, Dicer deletion delivered distinct lipid profile and increased lipid oxidation. Mechanically, Dicer deletion caused declined miR-192-3p and increased IGF2 in hepatocytes.

[Biophysical Journal] The authors showed that circulating tumor cells isolated from the blood of prostate cancer patients displayed specific nanomechanical phenotypes characteristic of cell endurance and invasiveness and patient sensitivity to androgen deprivation therapy.

[Journal of Cellular and Molecular Medicine] Researchers proposed to construct an immune-related prognostic risk model based on immune-related genes MMP14 and INHBA expression that could assess the prognosis of pancreatic cancer patients and identify potential therapeutic targets for pancreatic cancer, to provide new ideas for the treatment of pancreatic cancer.

[eLife] Tumor-associated macrophages (TAMs) are abundant, and they are important mediators of disease progression and invasion. Scientists generated tumor-educated macrophages in vitro and performed detailed, multiomic characterization.