Dicer Deletion in Hepatocytes Promotes Macrophages M1 Polarization through Dysregulated miR-192-3p/IGF2 in Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma

In hepatic cells, Dicer deletion delivered distinct lipid profile and increased lipid oxidation. Mechanically, Dicer deletion caused declined miR-192-3p and increased IGF2 in hepatocytes.