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myeloid cells

Tryptophan-Derived Microbial Metabolites Activate the Aryl Hydrocarbon Receptor in Tumor-Associated Macrophages to Suppress Anti-Tumor Immunity

[Immunity] Researchers examined the impact of aryl hydrocarbon receptor in tumor-associated macrophage function in pancreatic ductal adenocarcinoma.

Single-Cell Isoform Analysis in Human Immune Cells

[Genome Biology] The authors used R2C2 to sequence and demultiplex 12 million full-length cDNA molecules generated by the 10X Genomics platform from ~3000 peripheral blood mononuclear cells.

Ebola Virus Persistence and Disease Recrudescence in the Brains of Antibody-Treated Nonhuman Primate Survivors

[Science Translational Medicine] In monoclonal antibody-treated macaque survivors, Ebola virus disease persisted in macrophages infiltrating the brain ventricular system, including the choroid plexuses.

ADRB3 Induces Mobilization and Inhibits Differentiation of Both Breast Cancer Cells and Myeloid-Derived Suppressor Cells

[Cell Death & Disease] ADRB3 promoted metastasis by inducing mobilization and inhibiting differentiation of both breast cancer cells and myeloid-derived suppressor cells.

Human Umbilical Cord Mesenchymal Stem Cells Derived Exosomes Promote Neurological Function Recovery in a Rat Spinal Cord Injury Model

[Neurochemical Research] Researchers explored the mechanism of hUC-MSC derived exosome's ameliorative effect on the spinal cord injury by combining data from in vivo contusion spinal cord injury model and in vitro cell viability of PC12 cell line stimulated with lipopolysaccharide.

Glutaredoxin 1 Controls Monocyte Reprogramming during Nutrient Stress and Protects Mice against Obesity and Atherosclerosis in a Sex-Specific Manner

[Nature Communications] The authors reported that in chow-fed, reproductively senescent female mice but not in age-matched male mice, deficiency in the thiol transferase glutaredoxin 1 promoted dysregulated macrophage phenotypes as well as rapid weight gain and atherogenesis.

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