Glutaredoxin 1 Controls Monocyte Reprogramming during Nutrient Stress and Protects Mice against Obesity and Atherosclerosis in a Sex-Specific Manner

The authors reported that in chow-fed, reproductively senescent female mice but not in age-matched male mice, deficiency in the thiol transferase glutaredoxin 1 promoted dysregulated macrophage phenotypes as well as rapid weight gain and atherogenesis.