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myeloid cells

Single-Cell Analysis Reveals the Immune Characteristics of Myeloid Cells and Memory T Cells in Recovered COVID-19 Patients with Different Severities

[Frontiers in Immunology] According to large-scale single-cell analysis, recovered patients, who had severe symptoms, still exhibited peripheral immune disorders one-two months after symptom onset.

Progranulin Mediates Immune Evasion of Pancreatic Ductal Adenocarcinoma through Regulation of MHCI Expression

[Nature Communications] Researchers characterized the function of tumor-derived PGRN in promoting immune evasion in primary pancreatic ductal adenocarcinoma.

Fos Regulates Macrophage Infiltration against Surrounding Tissue Resistance by a Cortical Actin-Based Mechanism in Drosophila

[PLoS Biology] Investigators found that the tissue invasion of Drosophila macrophages, also known as plasmatocytes or hemocytes, utilized enhanced cortical F-actin levels stimulated by the Drosophila member of the fos proto oncogene transcription factor family.

CU06-1004 Enhances Vascular Integrity and Improves Cardiac Remodeling by Suppressing Edema and Inflammation in Myocardial Ischemia–Reperfusion Injury

[Experimental and Molecular Medicine] Investigators found that CU06-1004, as a vascular leakage blocker, could improve cardiac function by inhibiting cardiac microvascular endothelial cells' hyperpermeability and subsequently reducing the neutrophil’s plugging and infiltration in infarcted hearts.

LC3-Associated Phagocytosis in Bone Marrow Macrophages Suppresses Acute Myeloid Leukemia Progression through STING Activation

[Journal of Clinical Investigation] Scientists investigated the role of macrophage LC3-associated phagocytosis within the bone marrow microenvironment of acute myeloid leukemia.

Hepatic IRF8 Expression Suppresses Hepatocellular Carcinoma Progression and Enhances the Response to Anti-PD-1 Therapy

[Hepatology] Scientists identified interferon regulatory factor (IRF8) as an important prognostic biomarker in hepatocellular carcinoma patients which predicted the response and sensitivity to anti-PD-1 therapy.

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