Tag results:

myeloid cells

De-Escalation Antibiotic Therapy Alleviates Organ Injury through Modulation of NETs Formation during Sepsis

[Cell Death Discovery] Scientists evaluated the effect of imipenem and ceftriaxone on neutrophil extracellular traps (NETs) formation in vitro and examined the role of reactive oxygen species.

RNA Chaperone Activates Salmonella Virulence Program during Infection

[Nucleic Acids Research] Investigators reported that cold shock protein (CspC)—but not CspE—is necessary to activate the master virulence regulator PhoP when Salmonella enterica serovar Typhimurium experienced mildly acidic pH, such as inside macrophages.

HER3 is an Actionable Target in Advanced Prostate Cancer

[Cancer Research] Investigators showed that membranous HER3 protein was commonly highly expressed in lethal prostate cancer, associating with reduced time to castration resistance and survival.

Swiprosin-1 Deficiency in Macrophages Alleviated Atherogenesis

[Cell Death Discovery] Bone marrow transplantation was performed from swiprosin-1-knockout mice and age-matched ApoE−/− mice. Atherosclerotic lesion, serum lipid, and interleukin-β levels were detected.

Precise Delivery of Nanomedicines to M2 Macrophages by Combining “Eat Me/Don’t Eat Me” Signals and Its Anticancer Application

[ACS Nano] The authors developed a precise M2 TAM-targeted delivery system using “eat-me” and “don’t-eat-me” signals.

Genetic Inhibition of RIPK3 Ameliorates Functional Outcome in Controlled Cortical Impact Independent of Necroptosis

[Cell Death & Disease] Researchers used a model of cerebral contusion and receptor interacting protein kinase 3 (RIPK3) and mixed lineage kinase like knockout (MLKL−/−) mice, and found evidence for activation of RIPK3 and MLKL and assembly of a RIPK1-RIPK3-MLKL necrosome complex in pericontusional brain tissue.

Popular