myeloid cells

[Molecular Therapy] Scientists revealed that MSC-derived exosomes resided specifically in the injured kidney and delivered miRNA-34c-5p to reduce cellular activation and renal interstitial fibrosis by inhibiting core fucosylation.

[Stem Cell Reports] Scientists generated patient-derived CALRins5- or CALRdel52-positive iPSCs to establish a myeloproliferative neoplasms disease model for molecular and mechanistic studies.

[Nature Communications] In obesity, macrophages drive a low-grade systemic inflammation and insulin resistance. Scientists reported an unexpected location and function of NOC4L, which was preferentially expressed in human and mouse macrophages.

[Signal Transduction and Targeted Therapy] Macrophages are among the most abundant immune cells in colorectal cancer. Differentially expressed genes were found to be enriched in unfolded protein response/endoplasmic reticulum stress response processes, and XBP1 splicing/activation was specifically observed in tumor-associated macrophages.

[Molecular Therapy-Nucleic Acids] The authors reported DGUOK-AS1 overexpression promoted breast cancer cell migration, angiogenesis, and macrophage migration, mediated by the increased secretion of IL11, which was extremely important for cancer progression.

[Scientific Reports] Intraperitoneal injection of lipopolysaccharide and oral gavage of ampicillin increased IFN-γ and TNF-α expression in the spleen, colon, and hippocampus, while IL-10 expression decreased.