myeloid cells

[Journal of Nanobiotechnology] Effects of CD73+ human umbilical cord MSC-EVs on hydrolyzing ATP into adenosine were detected. The polarization of M2/M1 was verified by immunofluorescence.

[Immunity] Researchers review the multi-layered molecular mechanisms that underlie stimulus-specific gene expression in macrophages.

[Science Advances] The authors revealed that S100A9-deficient neutrophils produced higher levels of mitochondrial superoxide in response to Staphylococcus aureus and, as a result, form neutrophil extracellular traps.

[Journal of Nanobiotechnology] Scientists constructed CD73 modified extracellular vesicles and explored the anti-inflammatory effects after spinal cord injury. CD73 engineered extracellular vesicles were derived from human umbilical cord MSCs transduced by lentiviral vectors to upregulate the expression of CD73.

[Scientific Reports] Investigators characterized macrophages in hearts early infused with isoproterenol as compared to control and failing hearts and evaluated the role of upregulated CX3CL1 in cardiac remodeling.

[Cell Death Discovery] The authors showed dual regulatory functions of bone marrow-derived mesenchymal stem cells in attenuating hepatic fibrosis by promoting Ly6Chi/Ly6Clo subset conversion and Ly6Clo macrophage restoration through secreting antifibrogenic-cytokines and activating the apoptotic pathway.