myocardial infarction

[Journal of Cellular and Molecular Medicine] The authors found that the secretome obtained by human amniotic fluid-derived stem cells undergoing hypoxic preconditioning induced intracellular Ca2+ oscillations by promoting extracellular Ca2+ entry through Transient Receptor Potential Vanilloid 4.

[Cell Biology International] Cardiac function, myocardial infarction area, apoptosis, and angiogenesis were all evaluated in a CHF rat model following treatment with human umbilical cord MSC-derived exosomes.

[Circulation] Human induced pluripotent stem cell derived cardiomyocytes as well as ex vivo and in vivo models of ischemia-reperfusion injury were used to test the efficacy of ASIC1a inhibitors as pre- and post-conditioning therapeutic agents.

[Molecular Therapy] AAV9-mediated cardiac specific ADAR2 overexpression attenuated acute myocardial infarction (MI), MI remodeling and doxorubicin-induced cardiotoxicity. In vitro, overexpression of ADAR2 inhibited doxorubicin-induced cardiomyocyte apoptosis but also induced neonatal rat cardiomyocyte proliferation.

[Scientific Reports] Scientists investigated the role of GPR55 in cardiac physiology and post-myocardial infarction (MI) inflammation and remodeling. Global GPR55 deficiency mitigated MI-induced fetal gene re-programming and cardiomyocyte hypertrophy, culminating in aggravated LV dilatation and infarct expansion.

[Journal of Translational Medicine] The authors discuss the therapeutic potential of MSC- exosomes as an innovative approach in the context of regenerative medicine and highlight the recent knowledge on MSC- exosomes in translational medicine, focusing on in vivo researches.