ADAR2 Increases in Exercised Heart and Protects against Myocardial Infarction and Doxorubicin-Induced Cardiotoxicity

AAV9-mediated cardiac specific ADAR2 overexpression attenuated acute myocardial infarction (MI), MI remodeling and doxorubicin-induced cardiotoxicity. In vitro, overexpression of ADAR2 inhibited doxorubicin-induced cardiomyocyte apoptosis but also induced neonatal rat cardiomyocyte proliferation.