Natural Killer Cells

[Nature Aging] The authors revealed an atlas of age-related changes in the abundance and phenotype of immune cell populations across 12 mouse tissues.

[Nature Communications] The authors showed that despite a significant reduction in peripheral effector Treg cells, clinical responses are minimal in a cohort of patients with advanced CCR4-negative solid cancer in a Phase Ib study.

[Signal Transduction and Targeted Therapy] The authors combined analyses of immune cells and cytokine/chemokine networks with endothelial activation and injury.

[Cancer Science] Retrospective RNA-seq data analysis was conducted in a cohort of 313 patients with glioma in the Chinese Glioma Genome Atlas database and 603 patients in the TCGA database.

[Biomarkers] A new breakthrough development in cancer treatment is chimeric antigen receptor (CAR)-T cell therapy. The authors focus on its efficacy & safety in prostate cancer, obstacles impeding its clinical use, and some strategies trying to overcome them.

[Proceedings of the National Academy of Sciences of the United States of America] The authors showed that SSEA-4 was more expressed in all pancreatic cancer cell lines examined but not detectable in normal pancreatic cells.