Natural Killer Cells

[Cell Death & Disease] Scientists focused on understanding whether modulation of neddylation can regulate natural killer (NK) cell-activating ligands expression and sensitize multiple myeloma to NK cell killing.

[Aging-Us] Researchers established in vitro cultured mixed-natural killer cells (NKM) to achieve immune normalization. The in vitro cytotoxicity of NKM cells was tenfold higher than that of peripheral blood mononuclear cells

[Cell Reports] Researchers applied mass cytometry and uncover decidual-like natural killer cell subpopulations in newly diagnosed high-grade serous carcinoma samples that correlated with both tumor and transitioning epithelial-mesenchymal cell abundance.

[Cancer Immunology Research] Investigators engineered a Natural Killer cell line to express CD64, the sole human high-affinity IgG Fcγ receptor, and bound these cells with antibodies to provide interchangeable tumor-targeting elements.

[Cancer Gene Therapy] The authors discuss the importance of oncolytic viruses-based combination therapies in optimizing antiviral and antitumor innate immune responses stimulated by virotherapy toward tumor eradication, and how these processes vary depending on the tumor and oncolytic viruses in question.

[Journal of Immunology] The authors discovered that the expression of P2Y6 was decreased upon the activation of the NK cells. In the P2Y6-deficient mice, scientists found that the deficiency of P2Y6 promoted the development of the NK precursor cells into immature NK and mature NK cells.