neural cells

[Stem Cell Reports] Investigators used human embryonic stem cell-derived cortical organoids to investigate whether SARS-CoV-2 could infect brain tissue in vitro and found that cortical organoids could be infected at low viral titers and within six hours.

[Cell Death Discovery] Scientists determined the therapeutic potential of different human adipose tissue-derived-MSCs doses or their secreted extracellular vesicles, on human microglial cells that were activated by lipopolysaccharides

[Neuroscience Bulletin] To investigate whether the autism spectrum disorder-associated CHD7 intronic variant affects neural development, researchers established human embryonic stem cells carrying this variant using CRISPR/Cas9 methods and found that the level of CHD7 mRNA significantly decreased compared to control.

[PLoS One] The authors demonstrated that while low dose of GSK3β inhibitor CHIR 99021 increases organoid size, higher dose actually reduced organoid size; with the highest dose arresting organoid growth.

[Nature Communications] To characterize this potential distinctiveness, researchers used in vitro whole-cell recordings from cortical layers 2 and 3, layer 3c and layer 5 of the human cortex.

[Nature Communications] we developed a bioinformatics pipeline, centered on transcription factors co-occupancy of regulatory DNA, and used it to predict factors that potentiate the effects of pro-regenerative Klf6 in vitro.