we developed a bioinformatics pipeline, centered on transcription factors co-occupancy of regulatory DNA, and used it to predict factors that potentiate the effects of pro-regenerative Klf6 in vitro.
[Nature Communications]
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Venkatesh, I., Mehra, V., Wang, Z., Simpson, M. T., Eastwood, E., Chakraborty, A., Beine, Z., Gross, D., Cabahug, M., Olson, G., & Blackmore, M. G. (2021). Co-occupancy identifies transcription factor co-operation for axon growth. Nature Communications, 12(1), 2555. https://doi.org/10.1038/s41467-021-22828-3 Cite