neural cells

[Developmental Cell] The authors performed single-cell transcriptomics to define embryonic hypothalamic microglia heterogeneity and identified four microglial subsets, including a subpopulation adjacent to neural stem cells that was responsive to gestational cold stress.

[Cell Stem Cell] Investigators profiled the transcriptome of 43,261 cells derived from Rax+ hypothalamic neuroepithelium to map the developmental landscape of the mouse hypothalamus and trajectory of radial glial cells, intermediate progenitor cells, nascent neurons, and peptidergic neurons.

[Brain] Researchers investigated whether the neuroimmune dysregulation vascular phenotype was intrinsically compromised in the most common genetic risk factor for schizophrenia, the 22q11.2 deletion syndrome.

[Molecular Cancer Research] Researchers showed significant metabolic alterations occur in gliomas when perturbing the expression of asparagine synthetase, which is not merely restricted to amino acid homeostasis.

[Science Translational Medicine] The authors characterized the cellular properties and in vivo tissue repair activity of glial enriched progenitor cells differentiated from human-induced pluripotent stem cells.

[Molecular Psychiatry] Using multiple genetic approaches scientists showed that selective deletion of the PERK in mouse midbrain dopaminergic neurons resulted in multiple cognitive and motor phenotypes.