Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsThe authors characterized the cellular properties and in vivo tissue repair activity of glial enriched progenitor cells differentiated from human-induced pluripotent stem cells.
[Science Translational Medicine]
6807162 {6807162:6SDHDDXH} apa 50 1 161422 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-8d36b006147252f92aeec1a5d55aa7aa%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%226SDHDDXH%22%2C%22library%22%3A%7B%22id%22%3A6807162%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Llorente%20et%20al.%22%2C%22parsedDate%22%3A%222021-04-21%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELlorente%2C%20I.%20L.%2C%20Xie%2C%20Y.%2C%20Mazzitelli%2C%20J.%20A.%2C%20Hatanaka%2C%20E.%20A.%2C%20Cinkornpumin%2C%20J.%2C%20Miller%2C%20D.%20R.%2C%20Lin%2C%20Y.%2C%20Lowry%2C%20W.%20E.%2C%20%26amp%3B%20Carmichael%2C%20S.%20T.%20%282021%29.%20Patient-derived%20glial%20enriched%20progenitors%20repair%20functional%20deficits%20due%20to%20white%20matter%20stroke%20and%20vascular%20dementia%20in%20rodents.%20%3Ci%3EScience%20Translational%20Medicine%3C%5C%2Fi%3E%2C%20%3Ci%3E13%3C%5C%2Fi%3E%28590%29.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fscitranslmed.aaz6747%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1126%5C%2Fscitranslmed.aaz6747%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6807162%26amp%3Bitem_key%3D6SDHDDXH%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Patient-derived%20glial%20enriched%20progenitors%20repair%20functional%20deficits%20due%20to%20white%20matter%20stroke%20and%20vascular%20dementia%20in%20rodents%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Irene%20L.%22%2C%22lastName%22%3A%22Llorente%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yuan%22%2C%22lastName%22%3A%22Xie%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jose%20A.%22%2C%22lastName%22%3A%22Mazzitelli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emily%20A.%22%2C%22lastName%22%3A%22Hatanaka%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jessica%22%2C%22lastName%22%3A%22Cinkornpumin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20R.%22%2C%22lastName%22%3A%22Miller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ying%22%2C%22lastName%22%3A%22Lin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22William%20E.%22%2C%22lastName%22%3A%22Lowry%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22S.%20Thomas%22%2C%22lastName%22%3A%22Carmichael%22%7D%5D%2C%22abstractNote%22%3A%22Astro-therapy%20for%20stroke%5CnAstrocytes%2C%20axons%2C%20and%20myelin%20are%20subjected%20to%20major%20damage%20during%20subcortical%20white%20matter%20stroke%20%28WMS%29%2C%20a%20debilitating%20disorder%20leading%20to%20cognitive%20and%20motor%20impairments.%20Previous%20studies%20have%20shown%20that%20immature%20astrocyte%20transplantation%20could%20promote%20remyelination%20in%20rodent%20models.%20Now%2C%20Llorente%20et%20al.%20used%20a%20model%20of%20WMS%20in%20mice%20to%20demonstrate%20that%20transplantation%20of%20glial%20enriched%20progenitor%20cells%20differentiated%20from%20human-induced%20pluripotent%20stem%20cells%20%28hiPSC-GEPs%29%20shortly%20after%20stroke%20matured%20into%20a%20mature%20astrocyte%20phenotype%20and%20had%20therapeutic%20effect%20on%20axonal%20damage%2C%20demyelination%2C%20and%20cognitive%20impairments%20more%20effectively%20than%20hiPSC-derived%20neuronal%20precursor%20cells.%20The%20results%20suggest%20that%20astrocyte%20precursors%20have%20therapeutic%20potential%20in%20stroke.%5CnSubcortical%20white%20matter%20stroke%20%28WMS%29%20accounts%20for%20up%20to%2030%25%20of%20all%20stroke%20events.%20WMS%20damages%20primarily%20astrocytes%2C%20axons%2C%20oligodendrocytes%2C%20and%20myelin.%20We%20hypothesized%20that%20a%20therapeutic%20intervention%20targeting%20astrocytes%20would%20be%20ideally%20suited%20for%20brain%20repair%20after%20WMS.%20We%20characterize%20the%20cellular%20properties%20and%20in%20vivo%20tissue%20repair%20activity%20of%20glial%20enriched%20progenitor%20%28GEP%29%20cells%20differentiated%20from%20human-induced%20pluripotent%20stem%20cells%2C%20termed%20hiPSC-derived%20GEPs%20%28hiPSC-GEPs%29.%20hiPSC-GEPs%20are%20derived%20from%20hiPSC%5Cu2013neural%20progenitor%20cells%20via%20an%20experimental%20manipulation%20of%20hypoxia%20inducible%20factor%20activity%20by%20brief%20treatment%20with%20a%20prolyl%20hydroxylase%20inhibitor%2C%20deferoxamine.%20This%20treatment%20permanently%20biases%20these%20cells%20to%20further%20differentiate%20toward%20an%20astrocyte%20fate.%20hiPSC-GEPs%20transplanted%20into%20the%20brain%20in%20the%20subacute%20period%20after%20WMS%20in%20mice%20migrated%20widely%2C%20matured%20into%20astrocytes%20with%20a%20prorepair%20phenotype%2C%20induced%20endogenous%20oligodendrocyte%20precursor%20proliferation%20and%20remyelination%2C%20and%20promoted%20axonal%20sprouting.%20hiPSC-GEPs%20enhanced%20motor%20and%20cognitive%20recovery%20compared%20to%20other%20hiPSC-differentiated%20cell%20types.%20This%20approach%20establishes%20an%20hiPSC-derived%20product%20with%20easy%20scale-up%20capabilities%20that%20might%20be%20effective%20for%20treating%20WMS.%5CnA%20specific%20prorepair%20glial%20stem%20cell%20therapy%20promotes%20brain%20repair%20in%20vascular%20dementia%20in%20rodent%20models.%5CnA%20specific%20prorepair%20glial%20stem%20cell%20therapy%20promotes%20brain%20repair%20in%20vascular%20dementia%20in%20rodent%20models.%22%2C%22date%22%3A%222021%5C%2F04%5C%2F21%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1126%5C%2Fscitranslmed.aaz6747%22%2C%22ISSN%22%3A%221946-6234%2C%201946-6242%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fstm.sciencemag.org%5C%2Fcontent%5C%2F13%5C%2F590%5C%2Feaaz6747%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-04-21T21%3A59%3A53Z%22%7D%7D%5D%7D
Llorente, I. L., Xie, Y., Mazzitelli, J. A., Hatanaka, E. A., Cinkornpumin, J., Miller, D. R., Lin, Y., Lowry, W. E., & Carmichael, S. T. (2021). Patient-derived glial enriched progenitors repair functional deficits due to white matter stroke and vascular dementia in rodents. Science Translational Medicine, 13(590). https://doi.org/10.1126/scitranslmed.aaz6747 Cite
