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Astrocyte Plasticity in Mice Ensures Continued Endfoot Coverage of Cerebral Blood Vessels Following Injury and Declines with Age

[Nature Communications] The authors investigated if focal ablation of astrocytes were sufficient to disrupt the blood-brain barrier in mice. Targeted two-photon chemical apoptotic ablation of astrocytes induced a plasticity response whereby surrounding astrocytes extended processes to cover vascular vacancies.

$1.8M NIH Grant to Fund New Treatment for Stroke Patients

[Florida State University News] The National Institutes of Health (NIH) is funding a $1.8 million project led by a researcher at the Florida A and M Univeristy-Florida State University College of Engineering that will use artificially grown, simplified mini-organs to create medicine that targets brain cells damaged by stroke.

Athersys Reports That Its Partner, HEALIOS K.K., Provides Updates on MultiStem® Clinical Programs in Japan

[Athersys, Inc.] Athersys, Inc. announced that its partner, HEALIOS K.K. provided updates on its two clinical programs evaluating MultiStem® cell therapy, for which Healios has a license and is responsible for the development and commercialization of MultiStem for ischemic stroke and acute respiratory distress syndrome in Japan on an exclusive basis.

Neutrophil Extracellular Traps Regulate Ischemic Stroke Brain Injury

[Journal of Clinical Investigation] The authors observed increased plasma and platelet surface expressed high mobility group box 1 in stroke patients. Mechanistically, platelets were identified as the critical source for HMGB1 causing neutrophil extracellular trap in the acute phase of stroke.

Ozempic® 2.0 mg Approved in the US for the Treatment of Type 2 Diabetes

[Full Journal Title] Novo Nordisk announced that the FDA has approved a 2.0 mg dose of Ozempic® a glucagon-like peptide-1 analogue for the treatment of adults with type 2 diabetes.

Neurofunctional and Neuroimaging Readouts for Designing a Preclinical Stem-Cell Therapy Trial in Experimental Stroke

[Scientific Reports] With the aim of designing a preclinical study evaluating an intracerebral cell-based therapy for stroke, an observational study was performed in the rat suture model of ischemic stroke.