NogoA-Expressing Astrocytes Limit Peripheral Macrophage Infiltration after Ischemic Brain Injury in Primates

Utilizing single-nuclei transcriptomics to characterize astrocytes after ischemic stroke in the visual cortex of the marmoset monkey, researchers observed nearly complete segregation between stroke and control astrocyte clusters.
[Nature Communications]
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Towards Clinical Translation of ‘Second-Generation’ Regenerative Stroke Therapies: Hydrogels as Game Changers?

The authors suggest that a better understanding of human host stroke tissue–hydrogel interactions in addition to the effects of scaling up hydrogel volume to human-sized cavities would help guide the translation of second-generation regenerative stroke therapies.
[Trends in Biotechnology]
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Classification and Characteristics of Mesenchymal Stem Cells and Its Potential Therapeutic Mechanisms and Applications against Ischemic Stroke

Mesenchymal stem cell (MSC) transplantation therapy, which can trigger neuronal regeneration and repair, has been considered as a significant advance in treatment of ischemic stroke.
[Stem Cells International]
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Efficient Protein Incorporation and Release by a Jigsaw-Shaped Self-Assembling Peptide Hydrogel for Injured Brain Regeneration

Investigators developed a cell-adhesive fiber-forming peptide that mimicked the jigsaw-shaped hydrophobic surface in the dovetail-packing motif of glycophorin A as an artificial ECM for regenerative therapy.
[Nature Communications]
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Extracellular Vesicles from Hypoxia-Preconditioned Microglia Promote Angiogenesis and Repress Apoptosis in Stroke Mice via the TGF-β/Smad2/3 Pathway

By exposing bEnd.3 endothelial cells and primary cortical neurons to oxygen−glucose deprivation (OGD), the impact of extracellular vesicles from OGD-preconditioned microglia on angiogenesis and neuronal apoptosis by the tube formation assay and TUNEL staining was assessed.
[Cell Death & Disease]
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Genetic Inhibition of RIPK3 Ameliorates Functional Outcome in Controlled Cortical Impact Independent of Necroptosis

Researchers used a model of cerebral contusion and receptor interacting protein kinase 3 (RIPK3) and mixed lineage kinase like knockout (MLKL−/−) mice, and found evidence for activation of RIPK3 and MLKL and assembly of a RIPK1-RIPK3-MLKL necrosome complex in pericontusional brain tissue.
[Cell Death & Disease]
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proBDNF Expression Induces Apoptosis and Inhibits Synaptic Regeneration by Regulating the RhoA-JNK Pathway in an In Vitro Post-Stroke Depression Model

A post-stroke depression (PSD)-like model was established by treating neuronal cells with oxygen-glucose deprivation and corticosterone. Scientists found that protein pro-brain-derived neurotrophic factor (BDNF) levels were higher in the cortex and hippocampus in the PSD group than in the controls.
[Translational Psychiatry]
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Neuronal and Cardiac Toxicity of Pharmacological Compounds Identified through Transcriptomic Analysis of Human Pluripotent Stem Cell-Derived Embryoid Bodies

Scientists used human iPSC-derived embryoid bodies as an in vitro model to investigate the embryotoxic effects of a carefully selected set of pharmacological compounds.
[Toxicology and Applied Pharmacology]
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Clonal Hematopoiesis Is Associated With Higher Risk of Stroke

Clonal hematopoiesis of indeterminate potential (CHIP) is a novel age-related risk factor for cardiovascular disease–related morbidity and mortality. Researchers found that CHIP was associated with an increased risk of stroke, particularly with hemorrhagic and small vessel ischemic stroke.
[Stroke]
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Peripheral Immune Cells and Perinatal Brain Injury: A Double-Edged Sword?

Different immune cell subsets in perinatal brain injury including their infiltration routes are reviewed and critical aspects such as sex differences and maturational stage are discussed.
[Pediatric Research]
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Remote Limb Ischemic Postconditioning Protects Against Ischemic Stroke by Promoting Regulatory T Cells Thriving

The percentage of Tregs in the spleen, blood, and brain was detected using flow cytometry, and the number of Tregs in the ischemic hemisphere was counted using transgenic mice with an enhanced green fluorescent protein‐tagged Foxp3.
[Journal of the American Heart Association]
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