Nuclear WRAP53 Promotes Neuronal Survival and Functional Recovery After Stroke

Investigators found that DNA double-strand breaks (DSBs) in oxygen/glucose-deprived neurons spatiotemporally correlated with the up-regulation of WRAP53 (WD40-encoding p53-antisense RNA), which translocated to the nucleus to activate the DSB repair response.
[Science Advances]
Sánchez-Morán, I., Rodríguez, C., Lapresa, R., Agulla, J., Sobrino, T., Castillo, J., Bolaños, J. P., & Almeida, A. (2020). Nuclear WRAP53 promotes neuronal survival and functional recovery after stroke. Science Advances, 6(41), eabc5702. https://doi.org/10.1126/sciadv.abc5702 Cite
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Mesenchymal Stem Cells-Derived Mitochondria Transplantation Mitigates I/R-Induced Injury, Abolishes I/R-Induced Apoptosis, and Restores Motor Function in Acute Ischemia Stroke Rat Model

Investigators report that the mitochondrial transplantation ameliorated the reperfusion/ischemia-induced damages as reflected by declined blood creatine phosphokinase level, abolished apoptosis, decreased astroglyosis and microglia activation, reduced infarct size, and improved motor function.
[Brain Research Bulletin]
Pourmohammadi-Bejarpasi, Z., Roushandeh, A. M., Saberi, A., Rostami, M. K., Toosi, S. M. R., Jahanian-Najafabadi, A., Tomita, K., Kuwahara, Y., Sato, T., & Roudkenar, M. H. (2020). Mesenchymal stem cells-derived mitochondria transplantation mitigates I/R-induced injury, abolishes I/R-induced apoptosis, and restores motor function in acute ischemia stroke rat model. Brain Research Bulletin, 165, 70–80. https://doi.org/10.1016/j.brainresbull.2020.09.018 Cite
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Ninjurin 1 Dodecamer Peptide Containing the N-Terminal Adhesion Motif (N-NAM) Exerts Proangiogenic Effects in HUVECs and in the Postischemic Brain

Researchers examined the pro-angiogenic effect of N-NAM using human umbilical vein endothelial cells and the rat middle cerebral artery occlusion model of stroke.
[Scientific Reports]
Kim, S.-W., Lee, H.-K., Seol, S.-I., Davaanyam, D., Lee, H., & Lee, J.-K. (2020). Ninjurin 1 dodecamer peptide containing the N-terminal adhesion motif (N-NAM) exerts proangiogenic effects in HUVECs and in the postischemic brain. Scientific Reports, 10(1), 16656. https://doi.org/10.1038/s41598-020-73340-5 Cite
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National Institute of Neurological Disorders and Stroke Awards $3.8 Million to Cleveland Clinic Researcher to Predict Dementia in Parkinson’s Disease Patients

The National Institute of Neurological Disorders and Stroke at the National Institutes of Health awarded a grant total of $3.8 million to Virendra Mishra, Ph.D., associate staff at Cleveland Clinic Lou Ruvo Center for Brain Health, to identify biomarkers – or disease indicators – to predict dementia in patients with Parkinson’s disease.
[Cleveland Clinic]
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Intracerebral Transplants of GMP-Grade Human Umbilical Cord-Derived Mesenchymal Stromal Cells Effectively Treat Subacute-Phase Ischemic Stroke in a Rodent Model

Investigators compared the therapeutic effects of various delivery routes when administering Good Manufacturing Practice-grade human umbilical cord-MSCs in a rodent model of subacute-phase stroke.
[Frontiers in Cellular Neuroscience]
Noh, J.-E., Oh, S.-H., Park, I.-H., & Song, J. (2020). Intracerebral Transplants of GMP-Grade Human Umbilical Cord-Derived Mesenchymal Stromal Cells Effectively Treat Subacute-Phase Ischemic Stroke in a Rodent Model. Frontiers in Cellular Neuroscience, 14. https://doi.org/10.3389/fncel.2020.546659 Cite
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Dietary Docosahexaenoic Acid Inhibits Neurodegeneration and Prevents Stroke

Reviewers describe the effects of dietary docosahexaenoic acid on ischemic stroke‐associated neuronal damage and its role in stroke prevention.
[Journal of Neuroscience Research]
Yamagata, K. (n.d.). Dietary docosahexaenoic acid inhibits neurodegeneration and prevents stroke. Journal of Neuroscience Research, n/a(n/a). https://doi.org/10.1002/jnr.24728 Cite
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Pharmacological and Cardiovascular Perspectives on the Treatment of COVID-19 with Chloroquine Derivatives

While respiratory symptoms are the major clinical manifestations, cardiovascular abnormalities, including arrhythmias, myocarditis, heart failure, and ischemic stroke, have been reported in a significant number of COVID-19 patients.
[Acta Pharmacologica Sinica]
Zhang, X., Li, Z., Ye, J., Lu, J., Ye, L. L., Zhang, C., Liu, P., & Duan, D. D. (2020). Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives. Acta Pharmacologica Sinica, 1–10. https://doi.org/10.1038/s41401-020-00519-x Cite
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Stem/Progenitor Cell-Based Transplantation for Retinal Degeneration: A Review of Clinical Trials

Scientists provide a comprehensive overview on the progression of clinical trials for retinal degeneration treatment using four types of stem/progenitor cell-based transplantation to replace degenerative retinal cells and/or to supplement trophic factors from the aspects of safety, effectiveness and their respective advantages and disadvantages.
[Cell Death & Disease]
Wang, Y., Tang, Z., & Gu, P. (2020). Stem/progenitor cell-based transplantation for retinal degeneration: a review of clinical trials. Cell Death & Disease, 11(9), 1–14. https://doi.org/10.1038/s41419-020-02955-3 Cite
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Preventive Triple Gene Therapy Reduces the Negative Consequences of Ischemia-Induced Brain Injury after Modelling Stroke in a Rat

Adenoviral vectors carrying genes encoding vascular endothelial growth factor, glial cell-derived neurotrophic factor and neural cell adhesion molecule or gene engineered umbilical cord blood mononuclear cells overexpressing recombinant vascular endothelial growth factor, glial cell-derived neurotrophic factor, and neural cell adhesion molecule were intrathecally injected before distal occlusion of the middle cerebral artery in rats.
[International Journal of Molecular Sciences]
Markosyan, V., Safiullov, Z., Izmailov, A., Fadeev, F., Sokolov, M., Kuznetsov, M., Trofimov, D., Kim, E., Kundakchyan, G., Gibadullin, A., Salafutdinov, I., Nurullin, L., Bashirov, F., & Islamov, R. (2020). Preventive Triple Gene Therapy Reduces the Negative Consequences of Ischemia-Induced Brain Injury after Modelling Stroke in a Rat. International Journal of Molecular Sciences, 21(18), 6858. https://doi.org/10.3390/ijms21186858 Cite
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SIRT1/SIRT3 Modulates Redox Homeostasis during Ischemia/Reperfusion in the Aging Heart

The authors discuss the cellular and functional alterations upon ischemia/reperfusion (I/R) especially in aging hearts. They propose that mitochondria are the primary source of reactive oxygen species that contribute to I/R injury in aged hearts. Then, they highlight the cardiomyocyte protection of the age-related proteins Sirtuin1 and Sirtuin1 in response to I/R injury, and discuss their modulation of cardiac metabolism and the inflammatory reaction that is involved in ROS formation.
[Antioxidants]
Zhang, J., Ren, D., Fedorova, J., He, Z., & Li, J. (2020). SIRT1/SIRT3 Modulates Redox Homeostasis during Ischemia/Reperfusion in the Aging Heart. Antioxidants, 9(9), 858. https://doi.org/10.3390/antiox9090858 Cite
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Mannitol Augments the Effects of Systemical Stem Cell Transplantation without Increasing Cell Migration in a Stroke Animal Model

Researchers elucidated the neuroprotective effects of a combination of mannitol pretreatment and stem cell transplantation on stroke-induced neural injury.
[Journal of Tissue Engineering and Regenerative Medicine]
Lee, S.-H., Kang, H.-Y., Kim, J.-H., & Park, D.-H. (2020). Mannitol Augments the Effects of Systemical Stem Cell Transplantation without Increasing Cell Migration in a Stroke Animal Model. Tissue Engineering and Regenerative Medicine. https://doi.org/10.1007/s13770-020-00293-1 Cite
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