Researchers show the transplantation protocol for mesenchymal stem cells (MSCs), discuss the potential therapeutic mechanisms, and summarize clinical trials on MSCs for treating ischemic stroke.
[Journal of Neurology]
Researchers used single-cell RNA sequencing to characterize neurogenesis by notch-depleted striatal astrocytes in vivo.
Researchers investigated the effect of CM derived from human embryonic MSCs on experimental ischemic stroke.
[Journal of Cellular Physiology]
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Investigators showed a novel role of endothelin B receptors in neuronal progenitor cells and mitochondrial fate determination in cerebral ischemia, and in improving neurological deficit after stroke.
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The authors investigated the therapeutic potential of neural precursor cells derived from human HLA‐homozygous induced pluripotent stem cells following intracerebral transplantation into a rodent model of middle cerebral artery occlusion.
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Using a highly novel gene therapy approach in a canine, rapid atrial pacing model of atrial fibrillation, researchers demonstrated that NADPH oxidase 2 generated oxidative injury.
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Continue reading “Attenuation of Oxidative Injury with Targeted Expression of NOX2 shRNA Prevents Onset and Maintenance of Electrical Remodeling in the Canine Atrium: A Novel Gene Therapy Approach to Atrial Fibrillation”