Mesenchymal Stem Cell Therapy for Ischemic Stroke: A Look into Treatment Mechanism and Therapeutic Potential

Researchers show the transplantation protocol for mesenchymal stem cells (MSCs), discuss the potential therapeutic mechanisms, and summarize clinical trials on MSCs for treating ischemic stroke.
[Journal of Neurology]
Li, J., Zhang, Q., Wang, W., Lin, F., Wang, S., & Zhao, J. (2020). Mesenchymal stem cell therapy for ischemic stroke: A look into treatment mechanism and therapeutic potential. Journal of Neurology. https://doi.org/10.1007/s00415-020-10138-5 Cite
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Activation of a Neural Stem Cell Transcriptional Program in Parenchymal Astrocytes

Researchers used single-cell RNA sequencing to characterize neurogenesis by notch-depleted striatal astrocytes in vivo.
[eLife]
Activation of a neural stem cell transcriptional program in parenchymal astrocytes | eLife. (n.d.). Retrieved August 5, 2020, from https://elifesciences.org/articles/59733 Cite
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The Conditioned Medium of Human Embryonic Stem Cell‐Derived Mesenchymal Stem Cells Alleviates Neurological Deficits and Improves Synaptic Recovery in Experimental Stroke

Researchers investigated the effect of CM derived from human embryonic MSCs on experimental ischemic stroke.
[Journal of Cellular Physiology]
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Sovateltide (IRL-1620) Activates Neuronal Differentiation and Prevents Mitochondrial Dysfunction in Adult Mammalian Brains Following Stroke

Investigators showed a novel role of endothelin B receptors in neuronal progenitor cells and mitochondrial fate determination in cerebral ischemia, and in improving neurological deficit after stroke.
[Scientific Reports]
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Intracerebral Transplantation of HLA‐Homozygous Human iPSC‐Derived Neural Precursors Ameliorates the Behavioral and Pathological Deficits in a Rodent Model of Ischemic Stroke

The authors investigated the therapeutic potential of neural precursor cells derived from human HLA‐homozygous induced pluripotent stem cells following intracerebral transplantation into a rodent model of middle cerebral artery occlusion.
[Cell Proliferation]
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Attenuation of Oxidative Injury with Targeted Expression of NOX2 shRNA Prevents Onset and Maintenance of Electrical Remodeling in the Canine Atrium: A Novel Gene Therapy Approach to Atrial Fibrillation

Using a highly novel gene therapy approach in a canine, rapid atrial pacing model of atrial fibrillation, researchers demonstrated that NADPH oxidase 2 generated oxidative injury.
[Circulation]
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