neural cells

[Cancer Research] Investigators showed that LAMP2A expression was enriched in patient-derived glioblastoma stem cells (GSC), and its depletion diminished GSC-mediated tumorigenic activities.

[Angiogenesis] Scientists dissected vascular cues influencing glioblastoma stem cells (GSCs) gene expression and function to perfusion-based vascular cues, as well as to those requiring direct GSC-endothelial cell contacts.

[Brain] To model human malformations of cortical development associated with nitrogen permease regulator-like 3 (NPRL3) variants, researchers created a focal Nprl3 KO in fetal mouse cortex by in utero electroporation and found altered cortical lamination and white matter heterotopic neurons

[Brain] Scientists revealed a previously undefined cell type-specific role of 2-arachidonoylglycerol metabolism and signaling pathways in traumatic brain injury-induced neuropathology.

[Neuron] The authors review how the different autophagic pathways may protect against neurodegeneration, giving examples of both polygenic and monogenic diseases.

[Nature Protocols] Investigators described how to grow human PSCs such as human induced pluripotent and ESCs in a physically confined area and efficiently differentiate them into a highly enriched population of healthy and functional midbrain dopamine progenitors and midbrain dopamine neurons.