neural cells

[Stem Cell Research] Scientists generated human induced pluripotent stem cells from fibroblasts of a 64-year-old male patient with a homozygous ILE368ASN mutation in PINK1, who experienced disease onset at 33 years.

[Cell Reports] Employing human cerebral organoids, scientists found that chromodomain helicase DNA-binding 8 (CHD8) haploinsufficiency disrupted neurodevelopmental trajectories with an accelerated and delayed generation of, respectively, inhibitory and excitatory neurons that yields, at days 60 and 120, symmetrically opposite expansions in their proportions.

[Journal of Cancer] Investigators showed that miR-145-5p, a recently discovered miRNA, was expressed at low levels in primary glioma stem cells.

[Biomaterials] Exosomes from the conditioned medium (CM) of gingival MSC were isolated by ultracentrifugation and were injected into the vitreous of mice. The results showed that intraocular injection of TNF-α-stimulated gingival MSC into mice with ischemia-reperfusion injury notably reduced inflammation and cell loss than that with G-exos.

[Molecular Psychiatry] Scientists combined stem cell culturing with transplantation techniques to determine disease-specific properties inherent to autism spectrum disorder astrocytes.

[Cell Death & Disease] Researchers reported on the novel mechanism whereby overexpressed class I histone deacetylases increase the resistance of glioblastoma cells to the SN1 methylating agent temozolomide.