neural cells

[Fluids and Barriers of the CNS] Investigators applied a novel bioengineering approach to generate human blood-brain barrier organoids by the self-assembly of astrocytes, pericytes and brain endothelial cells with unprecedented throughput and reproducibility using micro patterned hydrogels.

[Cell Stem Cell] Xenotransplantation of human microglia into cerebral organoids allowed us to characterize key transcriptional programs of developing microglia in vitro and revealed that microglia induced transcriptional changes in neural stem cells and decrease interferon signaling response genes.

[Translational Psychiatry] Spinocerebellar ataxia type 3 (SCA3)-iPSCs could be corrected by the replacement of the abnormal CAG expansions with normal repeats using CRISPR/Cas9-mediated homologous recombination strategy. Corrected SCA3-iPSCs retained pluripotent and normal karyotype, which could be differentiated into a neural stem cell and neuronal cells.

[Molecular Psychiatry] Investigators used iPSC technology to obtain hippocampal neurons to investigate the neuropathology of IQSEC2-mediated disease. The neurons were characterized at three-time points during differentiation to assess developmental progression.

[Movement Disorders] The authors explore the opportunities and challenges resulting from the convergence of organoid high-throughput screening and AI-driven data analytics and outline potential future avenues toward the discovery of novel mechanisms and drugs in Parkinson's disease research.

[Scientific Reports] In search of novel putative therapeutic RNA targets researchers investigated the role of the oncogenic long noncoding RNA LINC00152 in A172 glioblastoma cells.