neural cells

[Nature Communications] Scientists showed that neuroinflammation, microhemorrhages, brain hypoxia, and neuropathology that is consistent with hypoxic-ischemic injury in SARS-CoV-2 infected non-human primates, including evidence of neuron degeneration and apoptosis.

[Science Signaling] With transgenic mice that expressed a dominant-negative mutant of the pore-forming Kir6.1 subunit specifically in brain capillary endothelial cells or pericytes, scientists demonstrated that ATP-sensitive K+ channels were present in both cell types and robustly controlled membrane potential.

[Nature Neuroscience] Using single-neuron reconstruction of 6,357 mouse prefrontal cortex (PFC) projection neurons, we identified 64 projectome-defined subtypes. Each of four previously known major cortico-cortical subnetworks was targeted by a distinct group of PFC subtypes defined by their first-order axon collaterals.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators found that targeting colony stimulating factor 1 (CSF-1) with neutralizing antibody halted ongoing encephalomyelitis, with efficacy superior to colony CSF-1 receptor inhibitor BLZ945, whereas IL-34 neutralization had no effect, suggesting that pathogenic myeloid cells were maintained by CSF-1.

[Molecular Therapy] Researchers reported that FOSL1, a component of AP-1 transcription factor complexes, was a key player in regulating PMT. FOSL1 was predominantly expressed in the mesenchymal subtype, but not proneural subtype of glioblastoma stem cells.

[Neuron] Investigators developed a cell atlas in which human and mouse trigeminal ganglia were transcriptionally and epigenomically profiled at single-cell resolution.