neural progenitor cells

[Scientific Reports] Researchers presented human patient induced pluripotent stem cell-derived neurons cultured on densely-spaced spiky silicon nanowire arrays which showed mature electrophysiological characteristics after only 20 days of culturing.

[Scientific Reports] Scientists used iPSCs from a patient carrying a p.A152T tau variant to create a robust, functional cellular assay system for probing pathophysiological tau accumulation and phosphorylation.

[Nature Communications] Researchers showed that the CCCTC-binding factor (CTCF) was a barrier for 2C-like reprogramming. Depletion of CTCF in ESCs efficiently promoted spontaneous and asynchronous conversion to a 2C-like state and was reversible upon restoration of CTCF levels.

[Science of the Total Environment] The authors identified that cadmium exposure specifically induced apoptosis in neurons and inhibited the proliferation of neural progenitor cells, but neural differentiation was not significantly affected in cerebral organoids.

[Stem Cell Reports] Investigators reported a new brain region-specific, microglia-containing organoid model by co-culturing human PSC-derived primitive neural progenitor cells and primitive macrophage progenitors.

[Cell Reports] Scientists investigated the contribution of the X-linked intellectual disability (XLID)-associated RBMX in neuronal differentiation.Transcriptomic analysis of isogenic Shashi-XLID human iPSCs generated using CRISPR-Cas9 revealed a dysregulation of MDM4 splicing and aberrant p53 upregulation.