neural stem cells

[Journal of Bioscience and Bioengineering] Researchers evaluated changes in extracellular vesicles morphology, concentration, and miRNA and protein expression in culture supernatants during the differentiation of iPSCs into neural lineage cells, for application in regenerative medicine for Parkinson's disease.

[Cell Reports] Using patient-derived human induced pluripotent stem cell-forebrain cerebral organoids (hCOs), researchers identified both neural stem cell proliferation and neuronal maturation abnormalities in neurofibromatosis type 1-total gene deletion hCOs.

[Nature Biomedical Engineering] Scientists showed that the neurotropism of Cryptococcus neoformans and its ability to penetrate the blood-brain barrier (BBB) could be modeled by the co-culture of human neural stem cells, brain microvascular endothelial cells and brain vascular pericytes in a human-neurovascular-unit-on-a-chip maintained by a stepwise gravity-driven unidirectional flow and recapitulating the structural and functional features of the BBB.

[International Journal of Molecular Sciences] Researchers report on the development of an enhanced synergistic combination therapy comprising polyacetal–curcumin nanoconjugate and neural stem cells derived from induced pluripotent stem cells + mesenchymal stem cells treatment as a treatment option for severe sub-acute traumatic spinal cord injury.

[Stem Cell Research & Therapy] Epothilone D could promote the neuronal differentiation of neural stem cells by upregulating Apol8, which might provide a promising therapeutic target for spinal cord injury repair.

[Cellular and Molecular Neurobiology] Researchers discuss the potential of prostaglandins as candidates for the development of new therapeutic drugs for motor neuron diseases.