Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsResearchers discuss the potential of prostaglandins as candidates for the development of new therapeutic drugs for motor neuron diseases.
[Cellular and Molecular Neurobiology]
7753456 RE8MB8PZ items 1 apa 0 default asc 1 162645 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-15d605890090d317a15ae2cd7f434731%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22RE8MB8PZ%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Nango%20and%20Kosuge%22%2C%22parsedDate%22%3A%222021-05-25%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ENango%2C%20H.%2C%20%26amp%3B%20Kosuge%2C%20Y.%20%282021%29.%20Present%20State%20and%20Future%20Perspectives%20of%20Prostaglandins%20as%20a%20Differentiation%20Factor%20in%20Motor%20Neurons.%20%3Ci%3ECellular%20and%20Molecular%20Neurobiology%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10571-021-01104-4%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10571-021-01104-4%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3DRE8MB8PZ%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Present%20State%20and%20Future%20Perspectives%20of%20Prostaglandins%20as%20a%20Differentiation%20Factor%20in%20Motor%20Neurons%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hiroshi%22%2C%22lastName%22%3A%22Nango%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yasuhiro%22%2C%22lastName%22%3A%22Kosuge%22%7D%5D%2C%22abstractNote%22%3A%22Spinal%20motor%20neurons%20have%20the%20longest%20axons%20that%20innervate%20the%20skeletal%20muscles%20of%20the%20central%20nervous%20system.%20Motor%20neuron%20diseases%20caused%20by%20spinal%20motor%20neuron%20cell%20death%20are%20incurable%20due%20to%20the%20unique%20and%20irreplaceable%20nature%20of%20their%20neural%20circuits.%20Understanding%20the%20mechanisms%20of%20neurogenesis%2C%20neuritogenesis%2C%20and%20synaptogenesis%20in%20motor%20neurons%20will%20allow%20investigators%20to%20develop%20new%20in%20vitro%20models%20and%20regenerative%20therapies%20for%20motor%20neuron%20diseases.%20In%20particular%2C%20small%20molecules%20can%20directly%20reprogram%20and%20convert%20into%20neural%20stem%20cells%20and%20neurons%2C%20and%20promote%20neuron-like%20cell%20differentiation.%20Prostaglandins%20are%20known%20to%20have%20a%20role%20in%20the%20differentiation%20and%20tissue%20regeneration%20of%20several%20cell%20types%20and%20organs.%20However%2C%20the%20involvement%20of%20prostaglandins%20in%20the%20differentiation%20of%20motor%20neurons%20from%20neural%20stem%20cells%20is%20poorly%20understood.%20The%20general%20cell%20line%20used%20in%20research%20on%20motor%20neuron%20diseases%20is%20the%20mouse%20neuroblastoma%20and%20spinal%20motor%20neuron%20fusion%20cell%20line%20NSC-34.%20Recently%2C%20our%20laboratory%20reported%20that%20prostaglandin%20E2%20and%20prostaglandin%20D2%20enhanced%20the%20conversion%20of%20NSC-34%20cells%20into%20motor%20neuron-like%20cells%20with%20neurite%20outgrowth.%20Moreover%2C%20we%20found%20that%20prostaglandin%20E2-differentiated%20NSC-34%20cells%20had%20physiological%20and%20electrophysiological%20properties%20of%20mature%20motor%20neurons.%20In%20this%20review%20article%2C%20we%20provide%20contemporary%20evidence%20on%20the%20effects%20of%20prostaglandins%2C%20particularly%20prostaglandin%20E2%20and%20prostaglandin%20D2%2C%20on%20differentiation%20and%20neural%20conversion.%20We%20also%20discuss%20the%20potential%20of%20prostaglandins%20as%20candidates%20for%20the%20development%20of%20new%20therapeutic%20drugs%20for%20motor%20neuron%20diseases.%22%2C%22date%22%3A%222021-05-25%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1007%5C%2Fs10571-021-01104-4%22%2C%22ISSN%22%3A%221573-6830%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs10571-021-01104-4%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%22TUURQW3H%22%5D%2C%22dateModified%22%3A%222021-05-26T19%3A10%3A58Z%22%7D%7D%5D%7D
Nango, H., & Kosuge, Y. (2021). Present State and Future Perspectives of Prostaglandins as a Differentiation Factor in Motor Neurons. Cellular and Molecular Neurobiology. https://doi.org/10.1007/s10571-021-01104-4 Cite
