Researchers used channelrhodopsin-2 transfected mouse ESC-derived motor neurons to explore short and long-term programming of neural networks by using optical stimulation implemented during neurogenesis and synaptogenesis.
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The authors investigated the therapeutic potential of neural precursor cells derived from human HLA‐homozygous induced pluripotent stem cells following intracerebral transplantation into a rodent model of middle cerebral artery occlusion.
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The authors performed cellular, kinematic, physiological, and anatomical analyses, either in vitro or in vivo, to comprehensively evaluate the safety and efficacy associated with subarachnoid transplantation of human umbilical cord mesenchymal stem cells in rats with subacute incomplete spinal cord injury.
[Experimental Cell Research]
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The authors identified a circuit involving dopamine-receptor expressing claustral neurons projecting to frontal cortex necessary for context association of reward.
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Terem, A., Gonzales, B. J., Peretz-Rivlin, N., Ashwal-Fluss, R., Bleistein, N., Reus-Garcia, M. del M., Mukherjee, D., Groysman, M., & Citri, A. (2020). Claustral Neurons Projecting to Frontal Cortex Mediate Contextual Association of Reward. Current Biology, 0(0). https://doi.org/10.1016/j.cub.2020.06.064 Cite
Scientists found that zeta inhibitory peptide induced redistribution of the AMPARGluA1 in HEK293 cells and primary cortical neurons, and decreased AMPAR-mediated currents in the nucleus accumbens.
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By taking advantage of a human induced pluripotent stem cell-based model, scientists aimed to gain insights on the impact of amyotrophic lateral sclerosis (ALS) mutant FUS on the motoneuron proteome.
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The authors identified distinct transcript changes in individual Piezo2-expressing mechanosensitive dorsal root ganglia neurons by combining electrophysiology with single-cell RNA sequencing.
Researchers investigated the efficacy and mechanism of the Bio 3D conduit composed of xeno-free human induced pluripotent stem cell–derived mesenchymal stem cells.
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Mitsuzawa, S., Zhao, C., Ikeguchi, R., Aoyama, T., Kamiya, D., Ando, M., Takeuchi, H., Akieda, S., Nakayama, K., Matsuda, S., & Ikeya, M. (2020). Pro-angiogenic scaffold-free Bio three-dimensional conduit developed from human induced pluripotent stem cell-derived mesenchymal stem cells promotes peripheral nerve regeneration. Scientific Reports, 10(1), 12034. https://doi.org/10.1038/s41598-020-68745-1 Cite
The Feinstein Institutes for Medical Research has been awarded a $15 million grant to study brain dysfunction tied to lupus by the National Institutes of Health. Betty Diamond, MD, director of the Feinstein’s Institute of Molecular Medicine, will use the five-year grant to investigate the role of anti-N-methyl D-aspartate receptor.
[The Feinstein Institutes for Medical Research (Business Wire, Inc.)]
The authors characterized neural precursor cells and their daughters at different stages of neurogenesis in the spiralian annelid Capitella teleta.
[BMC Evolutionary Biology]
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The authors discuss recent progress in understanding how interneuron subtypes are generated in vivo, and how that progress is being applied to the generation of rodent and human cortical interneurons in vitro.