neurons

[Nature Protocols] Investigators described how to grow human PSCs such as human induced pluripotent and ESCs in a physically confined area and efficiently differentiate them into a highly enriched population of healthy and functional midbrain dopamine progenitors and midbrain dopamine neurons.

[Advanced Science] The authors reported the engineering of a functional human neuronal network by mimicking the embryonic development of the spinal cord in a 3D dynamic biomaterial-based microenvironment.

[Scientific Reports] Researchers established motor nerve organoids from human PSCs with properties similar to those of neuromesodermal progenitors, a population of progenitor cells that comprise the caudal spinal cord.

[Nature Communications] Aberrant upregulation of the glycolytic enzyme PFKFB3 in neurons may contribute to CLN7 pathogenesis and targeting PFKFB3 could alleviate this and other lysosomal storage diseases.

[Acta Pharmacologica Sinica] The authors identified a natural product patchouli alcohol as a selective estrogen receptor β agonist which improved the cognitive defects in female APP/PS1 mice, and explored the underlying mechanisms.

[Cell Reports] Using inducible deletion of Sox5 or Sox6 in the adult mouse brain, the authors showed that both genes were required for radial glia-like morphology activation and the generation of new neurons.