neurons

[Neurology-Neuroimmunology & Neuroinflammation] Human CD8+ T lymphocytes from multiple sclerosis donors and age/sex-matched healthy controls were isolated to evaluate the functional impact of soluble ULBP4.

[Cell Stem Cell] Researchers developed an organoid assembly approach starting with cells from the three primary germ layers—enteric neuroglial, mesenchymal, and epithelial precursors—that were derived separately from human PSCs.

[Scientific Reports] The authors investigated cellular injury-induced processes in the presence of amyloid β (Aβ) pathology and exposed a co-culture system of cortical stem-cell derived astrocytes, neurons and oligodendrocytes to Aβ42 protofibrils prior to a mechanically induced scratch injury.

[eLife] Investigators reported a rapid protocol for the derivation of the human ATOH1 lineage, the precursor of excitatory cerebellar neurons, from human pluripotent stem cells.

[Nature Communications] The authors showed TDP-43 accumulation in intra-muscular nerves from amyotrophic lateral sclerosis (ALS) patients and in axons of human iPSC-derived motor neurons of ALS patients, as well as in motor neurons and neuromuscular junctions of a TDP-43 mislocalization mouse model.

[Cell Reports] Scientists performed chromatic immunoprecipitation sequencing ChIP-seq on cerebellum from spinocerebellar ataxia type 7 mice and observed increased H3K9-promoter acetylation in DNA repair genes, resulting in increased expression.