Traumatic Brain Injury in the Presence of Aβ Pathology Affects Neuronal Survival, Glial Activation and Autophagy

The authors investigated cellular injury-induced processes in the presence of amyloid β (Aβ) pathology and exposed a co-culture system of cortical stem-cell derived astrocytes, neurons and oligodendrocytes to Aβ42 protofibrils prior to a mechanically induced scratch injury.