neurons

[Stem Cell Reports] Researchers applied single-nuclei and single-cell transcriptomics to model interneuron development from human cortex and interneurons derived from PSCs, and provided a direct comparison of various in vitro interneuron derivation methods to determine the homogeneity achieved.

[Scientific Reports] Scientists reported the development of a novel, flowable, thermosensitive, injectable drug delivery system comprising bovine collagen (BC) and fibrinogen (FB) that formed a solid BC/FB gel immediately upon exposure to physiological conditions and could be used to deliver reparative drugs, such as the naturally occurring anti-inflammatory, anti-scarring agent Decorin, into adult rat spinal cord lesion sites.

[Scientific Reports] Scientists presented a transgenic, TAR DNA-binding protein-43 (TDP-43)-A315T, mouse model expressing an Amyotrophic Lateral Sclerosis (ALS) phenotype and demonstrated the presence of ubiquitinated cytoplasmic TDP-43 aggregates with > 80% cell death by 28 days post differentiation in vitro.

[Scientific Reports] Researchers presented a transgenic, TDP-43-A315T, mouse model expressing an amyotrophic lateral sclerosis phenotype and demonstrate the presence of ubiquitinated cytoplasmic TDP-43 aggregates with > 80% cell death by 28 days post differentiation in vitro.

[Nature Communications] Scientists showed that preformed α-syn fibrils increased the association between TLR2 and MyD88, resulting in microglial activation.

[Neuron] An inhibitory extracellular milieu and neuron-intrinsic processes prevent axons from regenerating in the adult central nervous system. Here scientists show how the two aspects are interwoven.