Thermosensitive Collagen/Fibrinogen Gels Loaded with Decorin Suppress Lesion Site Cavitation and Promote Functional Recovery after Spinal Cord Injury

Scientists reported the development of a novel, flowable, thermosensitive, injectable drug delivery system comprising bovine collagen (BC) and fibrinogen (FB) that formed a solid BC/FB gel immediately upon exposure to physiological conditions and could be used to deliver reparative drugs, such as the naturally occurring anti-inflammatory, anti-scarring agent Decorin, into adult rat spinal cord lesion sites.