neurons

[International Journal of Cardiology] For translation of our findings, investigators combined in vitro cytochemical, molecular and pharmacologic assays on human cardiac MSCs, from myocardial biopsies of healthy controls and arrhythmogenic cardiomyopathy (AC) patients, with the use of existing drugs to interfere with the predicted AC mechanisms.

[Journal of Molecular Neuroscience] After stimulation with Zeb2/Axin2-enriched BMSC exosomes, the spatial memory and nerve function of MCAO rats showed marked recovery. The number of neurons was increased in the subventricular zone, hippocampus, and cortex area, while the expression of nerve growth factors was upregulated.

[Cell Stem Cell] Around day 30, brain organoids attempted to assemble optic vesicles, which developed progressively as visible structures within 60 days. These optic vesicle-containing brain organoids constitute a developing optic vesicle’s cellular components, including primitive corneal epithelial and lens-like cells, retinal pigment epithelia, retinal progenitor cells, axon-like projections, and electrically active neuronal networks.

[Acta Pharmacologica Sinica] Researchers showed that CKLF1 was significantly up-regulated in cultured rat cortical neurons subjected to oxygen-glucose deprivation/reoxygenation (ODG/R) injury, but not in cultured rat microglia, astrocytes and oligodendrocytes.

[Nature Biomedical Engineering] Researchers used the model to track the infiltration of a number of candidate stem cells and to characterize the expression levels of genes associated with post-stroke pathologies.

[Molecular Psychiatry] To efficiently transform genetic associations into drug targets for Alzheimer’s disease, researchers employed an integrative analytical pipeline using proteomes in the brain and blood by systematically applying proteome-wide association study, Mendelian randomization and Bayesian colocalization.