Human Brain Organoids Assemble Functionally Integrated Bilateral Optic Vesicles

Around day 30, brain organoids attempted to assemble optic vesicles, which developed progressively as visible structures within 60 days. These optic vesicle-containing brain organoids constitute a developing optic vesicle’s cellular components, including primitive corneal epithelial and lens-like cells, retinal pigment epithelia, retinal progenitor cells, axon-like projections, and electrically active neuronal networks.