Human Brain Organoids Assemble Functionally Integrated Bilateral Optic Vesicles

By
Justin.choi
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Around day 30, brain organoids attempted to assemble optic vesicles, which developed progressively as visible structures within 60 days. These optic vesicle-containing brain organoids constitute a developing optic vesicle’s cellular components, including primitive corneal epithelial and lens-like cells, retinal pigment epithelia, retinal progenitor cells, axon-like projections, and electrically active neuronal networks.
[Cell Stem Cell]
Gabriel, E., Albanna, W., Pasquini, G., Ramani, A., Josipovic, N., Mariappan, A., Schinzel, F., Karch, C. M., Bao, G., Gottardo, M., Suren, A. A., Hescheler, J., Nagel-Wolfrum, K., Persico, V., Rizzoli, S. O., Altmüller, J., Riparbelli, M. G., Callaini, G., Goureau, O., … Gopalakrishnan, J. (2021). Human brain organoids assemble functionally integrated bilateral optic vesicles. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.07.010 Cite
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