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neurons

Cascade Diversification Directs Generation of Neuronal Diversity in the Hypothalamus

[Cell Stem Cell] Investigators profiled the transcriptome of 43,261 cells derived from Rax+ hypothalamic neuroepithelium to map the developmental landscape of the mouse hypothalamus and trajectory of radial glial cells, intermediate progenitor cells, nascent neurons, and peptidergic neurons.

Cell-Type-Specific Disruption of PERK-eIF2α Signaling in Dopaminergic Neurons Alters Motor and Cognitive Function

[Molecular Psychiatry] Using multiple genetic approaches scientists showed that selective deletion of the PERK in mouse midbrain dopaminergic neurons resulted in multiple cognitive and motor phenotypes.

High-Throughput Generation of Midbrain Dopaminergic Neuron Organoids from Reporter Human Pluripotent Stem Cells

[STAR Protocols] The authors describe a high-throughput 3D differentiation protocol for deriving midbrain dopaminergic neurons from human pluripotent stem cells.

The Relationship between Muscle Stem Cells and Motor Neurons

[Cellular and Molecular Life Sciences] Researchers discuss the relationship between muscle stem cells and motor neurons during Drosophila neuromuscular system development and adverse impact of affected muscle stem cell–motor neuron interactions in regenerating vertebrate muscle.

Exendin-4 Improves Long-Term Potentiation and Neuronal Dendritic Growth In Vivo and In Vitro Obesity Condition

[Scientific Reports] The authors identified the neuroprotective effect of exendin-4 in primary cultured hippocampal and cortical neurons in in vitro metabolic imbalanced condition.

Irx3 and Irx5 in Ins2-Cre+ Cells Regulate Hypothalamic Postnatal Neurogenesis and Leptin Response

[Nature Metabolism] Scientists identified radial glia-like neural stem cell population with high Irx3 and Irx5 expression in early postnatal hypothalamus and demonstrated that reduced dosage of Irx3 and Irx5 promoted neurogenesis in postnatal hypothalamus leading to elevated numbers of leptin-sensing arcuate neurons.

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