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Pulmonary Cell NewsScientists identified radial glia-like neural stem cell population with high Irx3 and Irx5 expression in early postnatal hypothalamus and demonstrated that reduced dosage of Irx3 and Irx5 promoted neurogenesis in postnatal hypothalamus leading to elevated numbers of leptin-sensing arcuate neurons.
[Nature Metabolism]
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Son, J. E., Dou, Z., Kim, K.-H., Wanggou, S., Cha, V. S. B., Mo, R., Zhang, X., Chen, X., Ketela, T., Li, X., Huang, X., & Hui, C. (2021). Irx3 and Irx5 in Ins2-Cre + cells regulate hypothalamic postnatal neurogenesis and leptin response. Nature Metabolism, 1–13. https://doi.org/10.1038/s42255-021-00382-y Cite
