Pro-Angiogenic Scaffold-Free Bio Three-Dimensional Conduit Developed from Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Promotes Peripheral Nerve Regeneration

Researchers investigated the efficacy and mechanism of the Bio 3D conduit composed of xeno-free human induced pluripotent stem cell–derived mesenchymal stem cells.
[Scientific Reports]
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Feinstein Institutes Receives $15 Million NIH Grant to Study Brain Dysfunction in Lupus

The Feinstein Institutes for Medical Research has been awarded a $15 million grant to study brain dysfunction tied to lupus by the National Institutes of Health. Betty Diamond, MD, director of the Feinstein’s Institute of Molecular Medicine, will use the five-year grant to investigate the role of anti-N-methyl D-aspartate receptor.
[The Feinstein Institutes for Medical Research (Business Wire, Inc.)]
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Investigating Cellular and Molecular Mechanisms of Neurogenesis in Capitella Teleta Sheds Light on the Ancestor of Annelida

The authors characterized neural precursor cells and their daughters at different stages of neurogenesis in the spiralian annelid Capitella teleta.
[BMC Evolutionary Biology]
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Generation of Cerebral Cortical GABAergic Interneurons from Pluripotent Stem Cells

The authors discuss recent progress in understanding how interneuron subtypes are generated in vivo, and how that progress is being applied to the generation of rodent and human cortical interneurons in vitro.
[Stem Cells]
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Transamniotic Mesenchymal Stem Cell Therapy for Neural Tube Defects Preserves Neural Function through Lesion-Specific Engraftment and Regeneration

Researchers report that transamniotic bone marrow-derived mesenchymal stem cell therapy for neural tube defects during early development may achieve beneficial functional recovery.
[Cell Death & Disease]
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Dextran-Coated Iron Oxide Nanoparticle-Induced Nanotoxicity in Neuron Cultures

The authors examined the dose-dependent neurotoxicity of dextran-coated iron oxide nanoparticles on cultured primary neurons harvested from postnatal day 0-1 mouse brains.
[Scientific Reports]
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Microglia Phagocytose Myelin Sheaths to Modify Developmental Myelination

To determine whether microglia also prune myelin sheaths, scientists used zebrafish to visualize and manipulate interactions between microglia, oligodendrocytes, and neurons during development.
[Nature Neuroscience]
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Spiking Neurons with Spatiotemporal Dynamics and Gain Modulation for Monolithically Integrated Memristive Neural Networks

Investigators demonstrated an artificial neuron based on NbOx volatile memristor that not only realized traditional all-or-nothing, threshold-driven spiking and spatiotemporal integration.
[Nature Communications]
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Pre-Clinical Study of Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitor Cells for Parkinson’s Disease

Scientists evaluated the safety and efficacy of dopaminergic progenitors (DAPs) derived from a clinical-grade human iPSC line. They confirmed the characteristics of DAPs by in vitro analyses.
[Nature Communications]
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C9orf72 Arginine-Rich Dipeptide Repeats Inhibit UPF1-Mediated RNA Decay via Translational Repression

Scientists showed that RNA decay mechanisms involving upstream frameshift, including nonsense-mediated decay, were inhibited in c9ALS/FTD brains and in cultured cells expressing either of two arginine-rich dipeptide repeats, poly(GR) and poly(PR).
[Nature Communications]
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Distinct Synchronization, Cortical Coupling and Behavioral Function of Two Basal Forebrain Cholinergic Neuron Types

Researchers recorded basal forebrain cholinergic neurons in vivo, to examine their behavioral functions, and in vitro, to study their intrinsic properties.
[Nature Neuroscience]
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