neutrophils

[Stem Cell Research & Therapy] Scientists provide an overview of bidirectional interactions between cancer stem cells and immune cells in gastric cancer, compiling relevant data about how CSCs can induce leukocyte reprogramming, resulting in pro-tumoral immune cells that orchestrate promotion of metastasis, chemoresistance, tumorigenicity, and even increase in number of cancer cells with stem properties.

[Nature Communications] Scientists found the chlamydial parasitophorous vacuole protein CT135 triggered NLRP3 inflammasome activation via TLR2/MyD88 signaling as a pathogenic strategy to evade neutrophil host defense.

[Bone Marrow Transplantation] Investigators analyzed 144 acute leukemia haploidentical hematopoietic-cell transplantation using post-transplant cyclophosphamide pediatric recipients; median age was ten years.

[BeiGene, Ltd.] BeiGene, Ltd. announced that BRUKINSA® (zanubrutinib) has received accelerated approval from the US FDA for the treatment of adult patients with relapsed or refractory marginal zone lymphoma who have received at least one anti-CD20-based regimen.

[Laboratory Investigation] Scientists investigated the roles of Lipocalin 2 (LCN2) in chronic inflammation and fibrosis, using repeated carbon tetrachloride in mineral-oil injection. Hepatic and serum LCN2 levels were remarkably higher in the mineral oil-injected wild type group compared to the CCl4.

[Science Advances] The authors revealed that S100A9-deficient neutrophils produced higher levels of mitochondrial superoxide in response to Staphylococcus aureus and, as a result, form neutrophil extracellular traps.