Chlamydia Evasion of Neutrophil Host Defense Results in NLRP3 Dependent Myeloid-Mediated Sterile Inflammation through the Purinergic P2X7 Receptor

Scientists found the chlamydial parasitophorous vacuole protein CT135 triggered NLRP3 inflammasome activation via TLR2/MyD88 signaling as a pathogenic strategy to evade neutrophil host defense.