neutrophils

[Pediatric Research] Scientists demonstrated that melatonin had several significant effects by reducing CD11b and TLR4 expression, attenuating TLR signaling, genes involved in the inflammasome and had the potential to reduce LPS-induced inflammatory responses.

[Molecular Therapy] Scientists used a targeted cancer therapy approach based on attenuated S. typhimurium engineered to express cytolysin A to target cancer stromal cells and cancer cells, and treat pancreatic cancer in mice.

[Scientific Reports] Scientists sought to understand how the programmed death ligand 1 inhibitor durvalumab and the immunomodulatory agent pomalidomide regulate immune cell activation and function in patients with relapsed/refractory multiple myeloma.

[Ecotoxicology and Environmental Safety] The authors demonstrated that hexavalent chromium inhibited the formation of neutrophil extracellular traps in rat peripheral blood and induced neutrophils apoptosis by inhibiting the AMP-activated protein kinase (AMPK) signaling pathway.

[Scientific Reports] Scientists investigated the effect of diesel exhaust particles (DEP) exposure on allergic rhinitis using a mouse model. BALB/c mice sensitized to house dust mite (HDM) were intranasally challenged with HDM in the presence and absence of DEP.

[Scientific Reports] To investigate the mechanism of cysteine protease cathepsin S (CTSS) in systemic lupus erythematosus (SLE), CTSS-overexpressing transgenic mice were generated, and induced lupus-like symptoms.