Overexpression of Cathepsin S Exacerbates Lupus Pathogenesis through Upregulation TLR7 and IFN-α in Transgenic Mice

To investigate the mechanism of cysteine protease cathepsin S (CTSS) in systemic lupus erythematosus (SLE), CTSS-overexpressing transgenic mice were generated, and induced lupus-like symptoms.