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Pulmonary Cell NewsTo investigate the mechanism of cysteine protease cathepsin S (CTSS) in systemic lupus erythematosus (SLE), CTSS-overexpressing transgenic mice were generated, and induced lupus-like symptoms.
[Scientific Reports]
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Lee, J., Jang, S., Choi, M., Kang, M., Lim, S.-G., Kim, S.-Y., Jang, S., Ko, J., Kim, E., Yi, J., Choo, Y., Kim, M. O., & Ryoo, Z. Y. (2021). Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-α in transgenic mice. Scientific Reports, 11(1), 16348. https://doi.org/10.1038/s41598-021-94855-5 Cite
