organoids

[iScience] Scientists used two forms of hiPSC-derived HMOX1-reporter renal organoids to probe their ability to detect nephrotoxicants in a panel of blind-coded compounds.

[Nature Protocols] The authors provided a reproducible protocol to robustly induce intestinal morphogenesis in a microfluidic gut-on-a-chip as well as in a Transwell-embedded hybrid chip.

[Molecular Cancer Research] Researchers found that combining p110β with RAC/PAK1 or tankyrase inhibitors significantly reduced the growth of murine and human CRPC organoids in vitro and in vivo.

[Advanced Science] The recent progress of organoids and organs-on-chips for virology research is summarized and their utility in meeting the COVID-19 pandemic is highlighted.

[Stem Cell Reports] By leveraging recent knowledge of the signaling pathways involved in liver development, investigators described a robust, scalable protocol that allowed them to consistently generate high-quality bipotent human hepatoblasts and hepatocyte-like cells from both ESCs and iPSCs.

[Cancer Cell] Investigators showed that, upon irradiation, interleukin-1α (IL-1α) not only polarized cancer-associated fibroblasts (CAFs) toward the inflammatory phenotype but also triggered oxidative DNA damage, thereby predisposing inflammatory CAFs to p53-mediated therapy-induced senescence, which in turn resulted in chemoradiotherapy resistance and disease progression.