organoids

[Life Sciences] The authors assessed the effective interactions of mesenchymal stem cells and human embryonic stem cells during retinal organoid formation.

[Nature Cell Biology] Using wild-type and a trapping-deficient poly (ADP-ribose) polymerase (PARP1) mutant combined with rapid immunoprecipitation mass spectrometry of endogenous proteins and Apex2 proximity labeling, investigators delineated mass spectrometry-based interactomes of trapped and non-trapped PARP1.

[Scientific Reports] This analysis protocol utilized morphological image processing to identify cellular structures within each image and quantify their circularity and size. Using this script, time-lapse images of aggregating and non-aggregating culture conditions are analyzed to profile early changes in size and circularity.

[Cell Death Discovery] Scientists reported gastric organoids established from tumor tissues comprising four signet ring cell carcinoma (SRCCs) and eight non-SRCCs.

[Cell Tissues Organs] Investigators developed a new method to generate 3D spatial-organized cardiac organoids from 2D micropatterned hiPSC colonies, instead of directly from 3D stem cell aggregates.

[Stem Cell Research & Therapy] Investigators discuss how stem cells play a role in the battle against COVID-19 and present a systematic review and prospective of the study on stem cell treatment and organoid models of COVID-19, which provides a reference for the effective control of the COVID-19 pandemic worldwide.