The Ubiquitin-Dependent ATPase p97 Removes Cytotoxic Trapped PARP1 from Chromatin

Using wild-type and a trapping-deficient poly (ADP-ribose) polymerase (PARP1) mutant combined with rapid immunoprecipitation mass spectrometry of endogenous proteins and Apex2 proximity labeling, investigators delineated mass spectrometry-based interactomes of trapped and non-trapped PARP1.