organoids

[Prellis Biologics, Inc. (Business Wire, Inc.)] Prellis Biologics, Inc. announced that it has entered into a multi-target drug discovery collaboration and licensing agreement with Bristol Myers Squibb utilizing Prellis Biologics’ first-in-class externalized human immune system based on human lymph node organoids.

[Advanced Materials] The authors reported a cyborg brain organoid platform, in which “tissue-like” stretchable mesh nanoelectronics are designed to match the mechanical properties of brain organoids and to be folded by the organogenetic process of progenitor or stem cells, distributing stretchable electrode arrays across the 3D organoids.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists established a role of de novo lipogenesis for mouse and human brain development and identified a link between progenitor-cell polarity and lipid metabolism.

[Nature Protocols] Scientists presented how to generate 3D spheroids resembling specific domains of the nervous system and then how to integrate them physically to allow axonal projections and synaptic assembly.

[Frontiers in Molecular Neuroscience] Investigators gather what is known about the impact of phenylalanine in the brain of patients and highlight where hiPSC-derived organoids could contribute to the understanding of this disease.

[Cell Reports] Scientists showed that Gpr17, an orphan G protein-coupled receptors, was co-expressed in glucagon-like peptide-1 (GLP-1)-expressing EECs in human and rodent intestinal epithelium.